Discovering novel SNPs that are correlated with patient outcome in a Singaporean cancer patient cohort treated with gemcitabine-based chemotherapy

Single Nucleotide Polymorphisms (SNPs) can influence patient outcome such as drug response and toxicity after drug intervention. The purpose of this study is to develop a systematic pathway approach to accurately and efficiently predict novel non-synonymous SNPs (nsSNPs) that could be causative to g...

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Main Authors:	Limviphuvadh, Vachiranee, Tan, Chee Seng, Konishi, Fumikazu, Jenjaroenpun, Piroon, Xiang, Joy Shengnan, Kremenska, Yuliya, Mu, Yar Soe, Soo, Ross A., Eisenhaber, Frank, Maurer-Stroh, Sebastian, Yong, Wei Peng, Nicholas, Syn, Chin, Lee Soo
Other Authors:	School of Computer Science and Engineering
Format:	Article
Language:	English
Published:	2018
Subjects:	Gemcitabine NSCLC
Online Access:	https://hdl.handle.net/10356/84498 http://hdl.handle.net/10220/45113
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Institution:	Nanyang Technological University
Language:	English

id	sg-ntu-dr.10356-84498
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spelling	sg-ntu-dr.10356-844982020-03-07T11:48:56Z Discovering novel SNPs that are correlated with patient outcome in a Singaporean cancer patient cohort treated with gemcitabine-based chemotherapy Limviphuvadh, Vachiranee Tan, Chee Seng Konishi, Fumikazu Jenjaroenpun, Piroon Xiang, Joy Shengnan Kremenska, Yuliya Mu, Yar Soe Soo, Ross A. Eisenhaber, Frank Maurer-Stroh, Sebastian Yong, Wei Peng Nicholas, Syn Chin, Lee Soo School of Computer Science and Engineering Gemcitabine NSCLC Single Nucleotide Polymorphisms (SNPs) can influence patient outcome such as drug response and toxicity after drug intervention. The purpose of this study is to develop a systematic pathway approach to accurately and efficiently predict novel non-synonymous SNPs (nsSNPs) that could be causative to gemcitabine-based chemotherapy treatment outcome in Singaporean non-small cell lung cancer (NSCLC) patients. NRF (Natl Research Foundation, S’pore) ASTAR (Agency for Sci., Tech. and Research, S’pore) MOE (Min. of Education, S’pore) Published version 2018-07-18T08:51:54Z 2019-12-06T15:46:09Z 2018-07-18T08:51:54Z 2019-12-06T15:46:09Z 2018 Journal Article Limviphuvadh, V., Tan, C. S., Konishi, F., Jenjaroenpun, P., Xiang, J. S., Kremenska, Y., et al. (2018). Discovering novel SNPs that are correlated with patient outcome in a Singaporean cancer patient cohort treated with gemcitabine-based chemotherapy. BMC Cancer, 18(1), 555-. 1471-2407 https://hdl.handle.net/10356/84498 http://hdl.handle.net/10220/45113 10.1186/s12885-018-4471-x en BMC Cancer © The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. 16 p. application/pdf
institution	Nanyang Technological University
building	NTU Library
country	Singapore
collection	DR-NTU
language	English
topic	Gemcitabine NSCLC
spellingShingle	Gemcitabine NSCLC Limviphuvadh, Vachiranee Tan, Chee Seng Konishi, Fumikazu Jenjaroenpun, Piroon Xiang, Joy Shengnan Kremenska, Yuliya Mu, Yar Soe Soo, Ross A. Eisenhaber, Frank Maurer-Stroh, Sebastian Yong, Wei Peng Nicholas, Syn Chin, Lee Soo Discovering novel SNPs that are correlated with patient outcome in a Singaporean cancer patient cohort treated with gemcitabine-based chemotherapy
description	Single Nucleotide Polymorphisms (SNPs) can influence patient outcome such as drug response and toxicity after drug intervention. The purpose of this study is to develop a systematic pathway approach to accurately and efficiently predict novel non-synonymous SNPs (nsSNPs) that could be causative to gemcitabine-based chemotherapy treatment outcome in Singaporean non-small cell lung cancer (NSCLC) patients.
author2	School of Computer Science and Engineering
author_facet	School of Computer Science and Engineering Limviphuvadh, Vachiranee Tan, Chee Seng Konishi, Fumikazu Jenjaroenpun, Piroon Xiang, Joy Shengnan Kremenska, Yuliya Mu, Yar Soe Soo, Ross A. Eisenhaber, Frank Maurer-Stroh, Sebastian Yong, Wei Peng Nicholas, Syn Chin, Lee Soo
format	Article
author	Limviphuvadh, Vachiranee Tan, Chee Seng Konishi, Fumikazu Jenjaroenpun, Piroon Xiang, Joy Shengnan Kremenska, Yuliya Mu, Yar Soe Soo, Ross A. Eisenhaber, Frank Maurer-Stroh, Sebastian Yong, Wei Peng Nicholas, Syn Chin, Lee Soo
author_sort	Limviphuvadh, Vachiranee
title	Discovering novel SNPs that are correlated with patient outcome in a Singaporean cancer patient cohort treated with gemcitabine-based chemotherapy
title_short	Discovering novel SNPs that are correlated with patient outcome in a Singaporean cancer patient cohort treated with gemcitabine-based chemotherapy
title_full	Discovering novel SNPs that are correlated with patient outcome in a Singaporean cancer patient cohort treated with gemcitabine-based chemotherapy
title_fullStr	Discovering novel SNPs that are correlated with patient outcome in a Singaporean cancer patient cohort treated with gemcitabine-based chemotherapy
title_full_unstemmed	Discovering novel SNPs that are correlated with patient outcome in a Singaporean cancer patient cohort treated with gemcitabine-based chemotherapy
title_sort	discovering novel snps that are correlated with patient outcome in a singaporean cancer patient cohort treated with gemcitabine-based chemotherapy
publishDate	2018
url	https://hdl.handle.net/10356/84498 http://hdl.handle.net/10220/45113
_version_	1681045427997114368

Discovering novel SNPs that are correlated with patient outcome in a Singaporean cancer patient cohort treated with gemcitabine-based chemotherapy

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