Inhibition of quorum sensing in a computational biofilm simulation

Bacteria communicate through small diffusible molecules in a process known as quorum sensing. Quorum-sensing inhibitors are compounds which interfere with this, providing a potential treatment for infections associated with bacterial biofilms. We present an individual-based computational model for a...

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Main Authors: Lees, M., Fozard, J. A., King, J. R., Logan, B. S.
Other Authors: School of Computer Engineering
Format: Article
Language:English
Published: 2013
Online Access:https://hdl.handle.net/10356/84502
http://hdl.handle.net/10220/12628
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-845022020-05-28T07:17:59Z Inhibition of quorum sensing in a computational biofilm simulation Lees, M. Fozard, J. A. King, J. R. Logan, B. S. School of Computer Engineering Bacteria communicate through small diffusible molecules in a process known as quorum sensing. Quorum-sensing inhibitors are compounds which interfere with this, providing a potential treatment for infections associated with bacterial biofilms. We present an individual-based computational model for a developing biofilm. Cells are aggregated into particles for computational efficiency, but the quorum-sensing mechanism is modelled as a stochastic process on the level of individual cells. Simulations are used to investigate different treatment regimens. The response to the addition of inhibitor is found to depend significantly on the form of the positive feedback in the quorum-sensing model; in cases where the model exhibits bistability, the time at which treatment is initiated proves to be critical for the effective prevention of quorum sensing and hence potentially of virulence. 2013-07-31T06:43:44Z 2019-12-06T15:46:11Z 2013-07-31T06:43:44Z 2019-12-06T15:46:11Z 2012 2012 Journal Article Fozard, J., Lees, M., King, J.,& Logan, B. (2012). Inhibition of quorum sensing in a computational biofilm simulation. Biosystems, 109(2), 105-114. 0303-2647 https://hdl.handle.net/10356/84502 http://hdl.handle.net/10220/12628 10.1016/j.biosystems.2012.02.002 en Biosystems
institution Nanyang Technological University
building NTU Library
country Singapore
collection DR-NTU
language English
description Bacteria communicate through small diffusible molecules in a process known as quorum sensing. Quorum-sensing inhibitors are compounds which interfere with this, providing a potential treatment for infections associated with bacterial biofilms. We present an individual-based computational model for a developing biofilm. Cells are aggregated into particles for computational efficiency, but the quorum-sensing mechanism is modelled as a stochastic process on the level of individual cells. Simulations are used to investigate different treatment regimens. The response to the addition of inhibitor is found to depend significantly on the form of the positive feedback in the quorum-sensing model; in cases where the model exhibits bistability, the time at which treatment is initiated proves to be critical for the effective prevention of quorum sensing and hence potentially of virulence.
author2 School of Computer Engineering
author_facet School of Computer Engineering
Lees, M.
Fozard, J. A.
King, J. R.
Logan, B. S.
format Article
author Lees, M.
Fozard, J. A.
King, J. R.
Logan, B. S.
spellingShingle Lees, M.
Fozard, J. A.
King, J. R.
Logan, B. S.
Inhibition of quorum sensing in a computational biofilm simulation
author_sort Lees, M.
title Inhibition of quorum sensing in a computational biofilm simulation
title_short Inhibition of quorum sensing in a computational biofilm simulation
title_full Inhibition of quorum sensing in a computational biofilm simulation
title_fullStr Inhibition of quorum sensing in a computational biofilm simulation
title_full_unstemmed Inhibition of quorum sensing in a computational biofilm simulation
title_sort inhibition of quorum sensing in a computational biofilm simulation
publishDate 2013
url https://hdl.handle.net/10356/84502
http://hdl.handle.net/10220/12628
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