Complex Copy Number Variation of AMY1 does not Associate with Obesity in two East Asian Cohorts

• Main Authors: Wasan, Pavandip S., Sheng, Liang, Marshall, Christian R., Scherer, Stephen W., Teo, Yik-Ying, Yong, Rita Y. Y., Su'Aidah Binte Mustaffa, Yap, Eric Peng Huat
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2016
• Subjects: Amylase 2A gene; Amylase 1 gene
• Online Access: https://hdl.handle.net/10356/84531; http://hdl.handle.net/10220/41899
• Institution: Nanyang Technological University

The human amylase gene locus at chromosome 1p21.1 is structurally complex. This region contains two pancreatic amylase genes, AMY2B, AMY2A, and a salivary gene AMY1. The AMY1 gene harbors extensive copy number variation (CNV), and recent studies have implicated this variation in adaptation to starch...