A Preliminary Study on the Extrusion Resolution of Pluronic F127 for Bioprinting Thermo-responsive Hydrogel Constructs

Thermo-responsive hydrogels have gained more attention recently due to their unique characteristic of tunable sol-gel transition when temperature is changed. They have been used for many biomedical applications from drug delivery to fabrication of soft tissue scaffolds via 3D bioprinting. In this pa...

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Main Authors: Suntornnond, Ratima, An, Jia, Chua, Chee Kai
Other Authors: School of Mechanical and Aerospace Engineering
Format: Conference or Workshop Item
Language:English
Published: 2016
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Online Access:https://hdl.handle.net/10356/84615
http://hdl.handle.net/10220/41814
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-846152020-09-24T20:14:16Z A Preliminary Study on the Extrusion Resolution of Pluronic F127 for Bioprinting Thermo-responsive Hydrogel Constructs Suntornnond, Ratima An, Jia Chua, Chee Kai School of Mechanical and Aerospace Engineering Proceedings of the 2nd International Conference on Progress in Additive Manufacturing (Pro-AM 2016) Singapore Centre for 3D Printing Bioprinting 3D printing Thermo-responsive hydrogels have gained more attention recently due to their unique characteristic of tunable sol-gel transition when temperature is changed. They have been used for many biomedical applications from drug delivery to fabrication of soft tissue scaffolds via 3D bioprinting. In this paper, the preliminary investigation on bioprinted thermo-responsive hydrogels were conducted in order to find out the correlations between size of nozzle, stage moving speed and gas pressure for achieving optimum printing resolution. The hydrogel that was used in this study was pluronic F127 at 24.5 wt % concentration. Two sizes of nozzle were used (25G and 30G) while stage moving speed (printing speed) and gas pressure were designed to be three levels each. A total of 18 experiments were conducted. The results show that the thinnest continuous line (highest resolution) of hydrogel could be obtained even when a larger nozzle is used. This paper suggests a relationship of the main parameters with the size of nozzle on extrusion based bioprinter, and the results from this study may provide a platform for future correlation studies on extrusion based bioprinting. NRF (Natl Research Foundation, S’pore) Published version 2016-12-12T06:57:00Z 2019-12-06T15:48:23Z 2016-12-12T06:57:00Z 2019-12-06T15:48:23Z 2016 Conference Paper Suntornnond, R., An, J., & Chua, C. K. (2016). A Preliminary Study on the Extrusion Resolution of Pluronic F127 for Bioprinting Thermo-responsive Hydrogel Constructs. Proceedings of the 2nd International Conference on Progress in Additive Manufacturing (Pro-AM 2016), 324-329. https://hdl.handle.net/10356/84615 http://hdl.handle.net/10220/41814 en © 2016 by Pro-AM 2016 Organizers. Published by Research Publishing, Singapore 6 p. application/pdf
institution Nanyang Technological University
building NTU Library
country Singapore
collection DR-NTU
language English
topic Bioprinting
3D printing
spellingShingle Bioprinting
3D printing
Suntornnond, Ratima
An, Jia
Chua, Chee Kai
A Preliminary Study on the Extrusion Resolution of Pluronic F127 for Bioprinting Thermo-responsive Hydrogel Constructs
description Thermo-responsive hydrogels have gained more attention recently due to their unique characteristic of tunable sol-gel transition when temperature is changed. They have been used for many biomedical applications from drug delivery to fabrication of soft tissue scaffolds via 3D bioprinting. In this paper, the preliminary investigation on bioprinted thermo-responsive hydrogels were conducted in order to find out the correlations between size of nozzle, stage moving speed and gas pressure for achieving optimum printing resolution. The hydrogel that was used in this study was pluronic F127 at 24.5 wt % concentration. Two sizes of nozzle were used (25G and 30G) while stage moving speed (printing speed) and gas pressure were designed to be three levels each. A total of 18 experiments were conducted. The results show that the thinnest continuous line (highest resolution) of hydrogel could be obtained even when a larger nozzle is used. This paper suggests a relationship of the main parameters with the size of nozzle on extrusion based bioprinter, and the results from this study may provide a platform for future correlation studies on extrusion based bioprinting.
author2 School of Mechanical and Aerospace Engineering
author_facet School of Mechanical and Aerospace Engineering
Suntornnond, Ratima
An, Jia
Chua, Chee Kai
format Conference or Workshop Item
author Suntornnond, Ratima
An, Jia
Chua, Chee Kai
author_sort Suntornnond, Ratima
title A Preliminary Study on the Extrusion Resolution of Pluronic F127 for Bioprinting Thermo-responsive Hydrogel Constructs
title_short A Preliminary Study on the Extrusion Resolution of Pluronic F127 for Bioprinting Thermo-responsive Hydrogel Constructs
title_full A Preliminary Study on the Extrusion Resolution of Pluronic F127 for Bioprinting Thermo-responsive Hydrogel Constructs
title_fullStr A Preliminary Study on the Extrusion Resolution of Pluronic F127 for Bioprinting Thermo-responsive Hydrogel Constructs
title_full_unstemmed A Preliminary Study on the Extrusion Resolution of Pluronic F127 for Bioprinting Thermo-responsive Hydrogel Constructs
title_sort preliminary study on the extrusion resolution of pluronic f127 for bioprinting thermo-responsive hydrogel constructs
publishDate 2016
url https://hdl.handle.net/10356/84615
http://hdl.handle.net/10220/41814
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