Irradiation of Epithelial Carcinoma Cells Upregulates Calcium-Binding Proteins That Promote Survival under Hypoxic Conditions

• Main Authors: Ren, Yan, Yeoh, Kheng Wei, Hao, Piliang, Kon, Oi Lian, Sze, Siu Kwan
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2016
• Subjects: Cancer; Calcium signaling
• Online Access: https://hdl.handle.net/10356/84713; http://hdl.handle.net/10220/41920
• Institution: Nanyang Technological University

Hypoxia is thought to promote tumor radio-resistance via effects on gene expression in cancer cells that modulate their metabolism, proliferation, and DNA repair pathways to enhance survival. Here we demonstrate for the first time that under hypoxic condition A431 epithelial carcinoma cells exhibit...