Metabolic drift in the aging brain

• Main Authors: Stauch, Kelly L., Petrascheck, Michael, Benton, H. Paul, Epstein, Adrian A., Fang, Mingliang, Gorantla, Santhi, Tran, Minerva, Hoang, Linh, Kurczy, Michael E., Boska, Michael D., Gendelman, Howard E., Fox, Howard S., Siuzdak, Gary, Ivanisevic, Julijana
• Other Authors: School of Civil and Environmental Engineering
• Format: Article
• Language: English
• Published: 2016
• Subjects: Metabolic drift; Healthy brain aging
• Online Access: https://hdl.handle.net/10356/84731; http://hdl.handle.net/10220/41964
• Institution: Nanyang Technological University

Brain function is highly dependent upon controlled energy metabolism whose loss heralds cognitive impairments. This is particularly notable in the aged individuals and in age-related neurodegenerative diseases. However, how metabolic homeostasis is disrupted in the aging brain is still poorly unders...