Controlled-release nanoencapsulating microcapsules to combat inflammatory diseases
The World Health Organization (WHO) has reported that globally 235 million people suffer from chronic and other inflammatory diseases. The short half-lives of nonsteroidal anti-inflammatory drugs (NSAIDs) and their notoriety in causing gastrointestinal discomforts, warrants these drugs to be release...
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sg-ntu-dr.10356-850772020-09-21T11:35:45Z Controlled-release nanoencapsulating microcapsules to combat inflammatory diseases Baek, Jong-Suep Yeo, Eng Wan Lee, Yin Hao Tan, Nguan Soon Loo, Say Chye Joachim School of Materials Science & Engineering School of Biological Sciences Singapore Centre for Environmental Life Sciences Engineering NSAIDs Multi-drug encapsulation The World Health Organization (WHO) has reported that globally 235 million people suffer from chronic and other inflammatory diseases. The short half-lives of nonsteroidal anti-inflammatory drugs (NSAIDs) and their notoriety in causing gastrointestinal discomforts, warrants these drugs to be released in a controlled and sustained manner. Although polymeric particles have been widely used for drug delivery, there are few reports that showcase their ability in encapsulating and sustaining the release of NSAIDs. In this paper, polymeric nanoencapsulating microcapsules loaded with NSAIDs were fabricated using solid/water/oil/water emulsion solvent evaporation method. Two NSAIDs, ibuprofen and naproxen, were first pre-loaded into nanoparticles and then encapsulated into a larger hollow microcapsule that contained the third NSAID, celecoxib. A high encapsulation efficiency (%) of these NSAIDs was achieved and a sustained release (up to 30 days) of these drugs in phosphate-buffered saline was observed. Then, a gastrointestinal drug – cimetidine (CIM) – was co-loaded with the NSAIDs. This floating delivery system exhibited excellent buoyancy (~88% up to 24 h) in simulated gastric fluid. It also allowed a sequential release of the drugs, whereby an immediate release of CIM followed by NSAIDs was observed. Drug release of the NSAIDs observed Fickian diffusion mechanism, whereas CIM observed non-Fickian diffusion. Therefore, this delivery system is a promising platform to control the delivery of NSAIDs to combat inflammatory diseases, thereby protecting against possible gastrointestinal side effects that may arise from the overuse of NSAIDs. MOE (Min. of Education, S’pore) Published version 2017-08-30T08:54:01Z 2019-12-06T15:56:34Z 2017-08-30T08:54:01Z 2019-12-06T15:56:34Z 2017 Journal Article Baek, J.-S., Yeo, E. W., Lee, Y. H., Tan, N. S., & Loo, S. C. J. (2017). Controlled-release nanoencapsulating microcapsules to combat inflammatory diseases. Drug Design, Development and Therapy, 11, 1707-1717. 1177-8881 https://hdl.handle.net/10356/85077 http://hdl.handle.net/10220/43653 10.2147/DDDT.S133344 en Drug Design, Development and Therapy © 2017 Baek et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). 11 p. application/pdf |
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NSAIDs Multi-drug encapsulation Baek, Jong-Suep Yeo, Eng Wan Lee, Yin Hao Tan, Nguan Soon Loo, Say Chye Joachim Controlled-release nanoencapsulating microcapsules to combat inflammatory diseases |
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The World Health Organization (WHO) has reported that globally 235 million people suffer from chronic and other inflammatory diseases. The short half-lives of nonsteroidal anti-inflammatory drugs (NSAIDs) and their notoriety in causing gastrointestinal discomforts, warrants these drugs to be released in a controlled and sustained manner. Although polymeric particles have been widely used for drug delivery, there are few reports that showcase their ability in encapsulating and sustaining the release of NSAIDs. In this paper, polymeric nanoencapsulating microcapsules loaded with NSAIDs were fabricated using solid/water/oil/water emulsion solvent evaporation method. Two NSAIDs, ibuprofen and naproxen, were first pre-loaded into nanoparticles and then encapsulated into a larger hollow microcapsule that contained the third NSAID, celecoxib. A high encapsulation efficiency (%) of these NSAIDs was achieved and a sustained release (up to 30 days) of these drugs in phosphate-buffered saline was observed. Then, a gastrointestinal drug – cimetidine (CIM) – was co-loaded with the NSAIDs. This floating delivery system exhibited excellent buoyancy (~88% up to 24 h) in simulated gastric fluid. It also allowed a sequential release of the drugs, whereby an immediate release of CIM followed by NSAIDs was observed. Drug release of the NSAIDs observed Fickian diffusion mechanism, whereas CIM observed non-Fickian diffusion. Therefore, this delivery system is a promising platform to control the delivery of NSAIDs to combat inflammatory diseases, thereby protecting against possible gastrointestinal side effects that may arise from the overuse of NSAIDs. |
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School of Materials Science & Engineering |
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School of Materials Science & Engineering Baek, Jong-Suep Yeo, Eng Wan Lee, Yin Hao Tan, Nguan Soon Loo, Say Chye Joachim |
format |
Article |
author |
Baek, Jong-Suep Yeo, Eng Wan Lee, Yin Hao Tan, Nguan Soon Loo, Say Chye Joachim |
author_sort |
Baek, Jong-Suep |
title |
Controlled-release nanoencapsulating microcapsules to combat inflammatory diseases |
title_short |
Controlled-release nanoencapsulating microcapsules to combat inflammatory diseases |
title_full |
Controlled-release nanoencapsulating microcapsules to combat inflammatory diseases |
title_fullStr |
Controlled-release nanoencapsulating microcapsules to combat inflammatory diseases |
title_full_unstemmed |
Controlled-release nanoencapsulating microcapsules to combat inflammatory diseases |
title_sort |
controlled-release nanoencapsulating microcapsules to combat inflammatory diseases |
publishDate |
2017 |
url |
https://hdl.handle.net/10356/85077 http://hdl.handle.net/10220/43653 |
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1681059308432785408 |