Investigation of human flap structure-specific endonuclease 1 (FEN1) activity on primer-template models and exploration of a substrate-based FEN1 inhibitor

• Main Authors: Wu, Haixia, Ye, Ruijuan, Huang, Dejian, Li, Tianhu, Ba, Sai, Zhang, Hao, Lee, Jasmine Yiqin
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2017
• Subjects: FEN1; Phosphorothioate
• Online Access: https://hdl.handle.net/10356/85086; http://hdl.handle.net/10220/43624
• Institution: Nanyang Technological University

Flap structure-specific endonuclease 1 (FEN1) is one of the enzymes that involve in Eukaryotic DNA replication and repair. Recent studies have proved that FEN1 is highly over-expressed in various types of cancer cells and is a drug target. However, a limited number of FEN1 inhibitors has been identi...