Alternative polyadenylation expands the mRNA isoform repertoire of human CD46

• Main Authors: Ly, Phuong Thao, Tang, Sze Jing, Roca, Xavier
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2017
• Subjects: Alternative polyadenylation; Intronic polyadenylation
• Online Access: https://hdl.handle.net/10356/85137; http://hdl.handle.net/10220/43664
• Institution: Nanyang Technological University

Alternative polyadenylation is a prevalent mechanism regulating mammalian gene expression. While tandem 3′-Untranslated-Region (3′UTR) polyadenylation changes expression levels, Intronic PolyAdenylation generates shorter transcripts encoding truncated proteins. Intronic PolyAdenylation regulates 20%...