Coarse-Grained Molecular Modeling of the Solution Structure Ensemble of Dengue Virus Nonstructural Protein 5 with Small-Angle X-ray Scattering Intensity

An ensemble-modeling scheme incorporating coarse-grained simulations with experimental small-angle X-ray scattering (SAXS) data is applied to dengue virus 2 (DENV2) nonstructural protein 5 (NS5). NS5 serves a key role in viral replication through its two domains that are connected by a 10-residue po...

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Bibliographic Details
Main Authors: Zhu, Guanhua, Saw, Wuan Geok, Nalaparaju, Anjaiah, Grüber, Gerhard, Lu, Lanyuan
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2017
Subjects:
Online Access:https://hdl.handle.net/10356/85140
http://hdl.handle.net/10220/43628
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Institution: Nanyang Technological University
Language: English