Mechanical strain alters cellular and nuclear dynamics at early stages of oligodendrocyte differentiation

• Main Authors: Makhija, Ekta, Jagielska, Anna, Zhu, Lena, Bost, Alexander C., Ong, William, Shivashankar, G. V., Van Vliet, Krystyn J., Chew, Sing Yian
• Other Authors: Interdisciplinary Graduate School (IGS)
• Format: Article
• Language: English
• Published: 2018
• Subjects: Oligodendrocyte Differentiation; Strain
• Online Access: https://hdl.handle.net/10356/85192; http://hdl.handle.net/10220/45095
• Institution: Nanyang Technological University

Mechanical and physical stimuli including material stiffness and topography or applied mechanical strain have been demonstrated to modulate differentiation of glial progenitor and neural stem cells. Recent studies probing such mechanotransduction in oligodendrocytes have focused chiefly on the biomo...