Cell-free hemoglobin mediated oxidative stress is associated with acute kidney injury and renal replacement therapy in severe falciparum malaria: an observational study

• Main Authors: Plewes, Katherine, Kingston, Hugh W.F., Ghose, Aniruddha, Maude, Richard J., Herdman, M. Trent, Leopold, Stije J., Ishioka, Haruhiko, Hasan, Md. Mahtab Uddin, Haider, Md. Shafiul, Alam, Shamsul, Piera, Kim A., Charunwatthana, Prakaykaew, Silamut, Kamolrat, Yeo, Tsin Wen, Faiz, Md. Abul, Lee, Sue J., Mukaka, Mavuto, Turner, Gareth D. H., Anstey, Nicholas M., Jackson Roberts II, L., White, Nicholas J., Day, Nicholas P. J., Hossain, Md. Amir, Dondorp, Arjen M.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2017
• Subjects: Acute kidney injury; Pathophysiology
• Online Access: https://hdl.handle.net/10356/85197; http://hdl.handle.net/10220/43680
• Institution: Nanyang Technological University

Background: Intravascular hemolysis is an intrinsic feature of severe malaria pathophysiology but the pathogenic role of cell-free hemoglobin-mediated oxidative stress in severe malaria associated acute kidney injury (AKI) is unknown. Methods: As part of a prospective observational study, enrolment...