Increased intracellular cyclic di-AMP levels sensitize Streptococcus gallolyticus subsp. gallolyticus to osmotic stress and reduce biofilm formation and adherence on intestinal cells

• Main Authors: Teh, Wooi Keong, Dramsi, Shaynoor, Tolker-Nielsen, Tim, Yang, Liang, Givskov, Michael
• Other Authors: Galperin, Michael Y.
• Format: Article
• Language: English
• Published: 2019
• Subjects: C-di-AMP; DRNTU::Science::Biological sciences; Streptococcus gallolyticus
• Online Access: https://hdl.handle.net/10356/85354; http://hdl.handle.net/10220/48383
• Institution: Nanyang Technological University

Cyclic di-AMP is a recently identified second messenger exploited by a number of Gram-positive bacteria to regulate important biological processes. Here, we studied the phenotypic alterations induced by the increased intracellular c-di-AMP levels in Streptococcus gallolyticus, an opportunistic patho...