Enhancing the sensitivity of micro magnetic resonance relaxometry detection of low parasitemia Plasmodium falciparum in human blood

• Main Authors: Thamarath, Smitha Surendran, Xiong, Aoli, Lin, Po-Han, Preiser, Peter Rainer, Han, Jongyoon
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2019
• Subjects: DRNTU::Science::Biological sciences; Biochemical Assays; Malaria
• Online Access: https://hdl.handle.net/10356/85506; http://hdl.handle.net/10220/48224
• Institution: Nanyang Technological University

Upon Plasmodium falciparum infection of the red blood cells (RBCs), the parasite replicates and consumes haemoglobin resulting in the release of free heme which is rapidly converted to hemozoin crystallites. The bulk magnetic susceptibility of infected RBCs (iRBCs) is changed due to ferric (Fe3+) pa...