Intra-epidemic evolutionary dynamics of a dengue virus type 1 population reveal mutant spectra that correlate with disease transmission

• Main Authors: Hapuarachchi, Hapuarachchige Chanditha, Koo, Carmen, Kek, Relus, Xu, Helen, Lai, Yee Ling, Liu, Lilac, Kok, Suet Yheng, Shi, Yuan, Lee, Kim-Sung, Maurer-Stroh, Sebastian, Ng, Lee Ching, Lee, Raphael Tze Chuen
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2018
• Subjects: Dengue Virus; Epidemics; DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/85513; http://hdl.handle.net/10220/46686
• Institution: Nanyang Technological University

Dengue virus (DENV) is currently the most prevalent mosquito-borne viral pathogen. DENVs naturally exist as highly heterogeneous populations. Even though the descriptions on DENV diversity are plentiful, only a few studies have narrated the dynamics of intra-epidemic virus diversity at a fine scale....