Dynamic in vivo imaging of small animal brain using pulsed laser diode-based photoacoustic tomography system

We demonstrate dynamic in vivo imaging using a low-cost portable pulsed laser diode based photoacoustic tomography system. The system takes advantage of an 803 nm pulsed laser diode having high repetition rate ~7000 Hz combined with a fast-scanning single-element ultrasound transducer leading to a 5...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Upputuri, Paul Kumar, Pramanik, Manojit
مؤلفون آخرون: School of Chemical and Biomedical Engineering
التنسيق: مقال
اللغة:English
منشور في: 2017
الموضوعات:
الوصول للمادة أونلاين:https://hdl.handle.net/10356/85619
http://hdl.handle.net/10220/43801
الوسوم: إضافة وسم
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المؤسسة: Nanyang Technological University
اللغة: English
الوصف
الملخص:We demonstrate dynamic in vivo imaging using a low-cost portable pulsed laser diode based photoacoustic tomography system. The system takes advantage of an 803 nm pulsed laser diode having high repetition rate ~7000 Hz combined with a fast-scanning single-element ultrasound transducer leading to a 5 seconds cross-sectional imaging. Cortical vasculature is imaged in scan-time of 5 seconds with high signal-to-noise ratio ~48. To examine the ability for dynamic imaging, we monitored the fast uptake and clearance process of indo-cyanine green in the rat brain. The system will find applications to study neuro-functional activities, characterization of pharmacokinetic and bio-distribution profiles in the development process of drugs or imaging agents.