Dynamic in vivo imaging of small animal brain using pulsed laser diode-based photoacoustic tomography system
We demonstrate dynamic in vivo imaging using a low-cost portable pulsed laser diode based photoacoustic tomography system. The system takes advantage of an 803 nm pulsed laser diode having high repetition rate ~7000 Hz combined with a fast-scanning single-element ultrasound transducer leading to a 5...
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| Main Authors: | , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
2017
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/85619 http://hdl.handle.net/10220/43801 |
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| Institution: | Nanyang Technological University |
| Language: | English |
| Summary: | We demonstrate dynamic in vivo imaging using a low-cost portable pulsed laser diode based photoacoustic tomography system. The system takes advantage of an 803 nm pulsed laser diode having high repetition rate ~7000 Hz combined with a fast-scanning single-element ultrasound transducer leading to a 5 seconds cross-sectional imaging. Cortical vasculature is imaged in scan-time of 5 seconds with high signal-to-noise ratio ~48. To examine the ability for dynamic imaging, we monitored the fast uptake and clearance process of indo-cyanine green in the rat brain. The system will find applications to study neuro-functional activities, characterization of pharmacokinetic and bio-distribution profiles in the development process of drugs or imaging agents. |
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