Cellular- and network-level regulation of place cell activity mediated by activity-dependent gene, Arc

Activity-regulated cytoskeleton-associated protein (Arc), is suggested to be an important mediator of activity-dependent changes in the brain. It bridges experience with synaptic modification and is critical for long-term memory. Despite the accumulating findings that Arc regulates synaptic plastici...

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Main Author: Yuan, Li
Other Authors: Ayumu Tashiro
Format: Theses and Dissertations
Language:English
Published: 2019
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Online Access:https://hdl.handle.net/10356/85646
http://hdl.handle.net/10220/49828
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-856462023-02-28T18:33:05Z Cellular- and network-level regulation of place cell activity mediated by activity-dependent gene, Arc Yuan, Li Ayumu Tashiro School of Biological Sciences Science::Biological sciences Activity-regulated cytoskeleton-associated protein (Arc), is suggested to be an important mediator of activity-dependent changes in the brain. It bridges experience with synaptic modification and is critical for long-term memory. Despite the accumulating findings that Arc regulates synaptic plasticity and memory, how Arc contributes to the generation of neuronal firing pattern is not clear. In this study, we aim to understand what aspects of behaviorally-relevant neuronal activity is regulated by Arc. For this purpose, we used place cells as a model, and examined how interfering the expression of Arc gene affects place cell activity in freely moving rats. Our result suggests that Arc increases firing rate and broadens the tuning of spatiotemporal neuronal firing activity at the cellular level, which in turn improves population functions. This cellular- and network-level firing patterns regulated by an experience-induced gene might contribute to the formation of memory engram. Doctor of Philosophy 2019-09-02T00:15:59Z 2019-12-06T16:07:48Z 2019-09-02T00:15:59Z 2019-12-06T16:07:48Z 2019 Thesis Yuan, L. (2019). Cellular- and network-level regulation of place cell activity mediated by activity-dependent gene, Arc. Doctoral thesis, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/85646 http://hdl.handle.net/10220/49828 10.32657/10220/49828 en 126 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Science::Biological sciences
spellingShingle Science::Biological sciences
Yuan, Li
Cellular- and network-level regulation of place cell activity mediated by activity-dependent gene, Arc
description Activity-regulated cytoskeleton-associated protein (Arc), is suggested to be an important mediator of activity-dependent changes in the brain. It bridges experience with synaptic modification and is critical for long-term memory. Despite the accumulating findings that Arc regulates synaptic plasticity and memory, how Arc contributes to the generation of neuronal firing pattern is not clear. In this study, we aim to understand what aspects of behaviorally-relevant neuronal activity is regulated by Arc. For this purpose, we used place cells as a model, and examined how interfering the expression of Arc gene affects place cell activity in freely moving rats. Our result suggests that Arc increases firing rate and broadens the tuning of spatiotemporal neuronal firing activity at the cellular level, which in turn improves population functions. This cellular- and network-level firing patterns regulated by an experience-induced gene might contribute to the formation of memory engram.
author2 Ayumu Tashiro
author_facet Ayumu Tashiro
Yuan, Li
format Theses and Dissertations
author Yuan, Li
author_sort Yuan, Li
title Cellular- and network-level regulation of place cell activity mediated by activity-dependent gene, Arc
title_short Cellular- and network-level regulation of place cell activity mediated by activity-dependent gene, Arc
title_full Cellular- and network-level regulation of place cell activity mediated by activity-dependent gene, Arc
title_fullStr Cellular- and network-level regulation of place cell activity mediated by activity-dependent gene, Arc
title_full_unstemmed Cellular- and network-level regulation of place cell activity mediated by activity-dependent gene, Arc
title_sort cellular- and network-level regulation of place cell activity mediated by activity-dependent gene, arc
publishDate 2019
url https://hdl.handle.net/10356/85646
http://hdl.handle.net/10220/49828
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