mTORC2/Akt activation in adipocytes is required for adipose tissue inflammation in tuberculosis

• Main Authors: Martinez, Nuria, Cheng, Catherine Y., Ketheesan, Natkunam, Cullen, Aidan, Tang, Yuefeng, Lum, Josephine, West, Kim, Poidinger, Michael, Guertin, David A., Singhal, Amit, Kornfeld, Hardy
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2019
• Subjects: Tuberculosis; Adipose Tissue; Science::Medicine
• Online Access: https://hdl.handle.net/10356/85649; http://hdl.handle.net/10220/49820
• Institution: Nanyang Technological University

Background: Mycobacterium tuberculosis has co-evolved with the human host, adapting to exploit the immune system for persistence and transmission. While immunity to tuberculosis (TB) has been intensively studied in the lung and lymphoid system, little is known about the participation of adipose tiss...