Ezh2 controls skin tolerance through distinct mechanisms in different subsets of skin dendritic cells

• Main Authors: Morita, Akimichi, Ginhoux, Florent, Loh, Jia Tong, Lim, Thomas Jun Feng, Ikumi, Kyoko, Matoba, Takuma, Janela, Baptiste, Gunawan, Merry, Toyama, Tatsuya, Bunjamin, Maegan, Ng, Lai Guan, Poidinger, Michael, Yamazaki, Sayuri, Lam, Kong-Peng, Su, I-hsin
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2019
• Subjects: Dermatology; Immunology; Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/85704; http://hdl.handle.net/10220/49842
• Institution: Nanyang Technological University

Ezh2, a well-established epigenetic repressor, can down-regulate leukocyte inflammatory responses, but its role in cutaneous health remains elusive. Here we demonstrate that Ezh2 controls cutaneous tolerance by regulating Langerhans cell (LC) transmigration across the epidermal basement membrane dir...