Local release of rapamycin by microparticles delays islet rejection within the anterior chamber of the eye

• Main Authors: Fan, Yanliang, Zheng, Xiaofeng, Berggren, Per-Olof, Loo, Joachim Say Chye, Yusuf Ali
• Other Authors: School of Materials Science & Engineering
• Format: Article
• Language: English
• Published: 2019
• Subjects: DRNTU::Science::Medicine; Allotransplantation; Drug Delivery
• Online Access: https://hdl.handle.net/10356/85922; http://hdl.handle.net/10220/48270
• Institution: Nanyang Technological University

The anterior chamber of the eye (ACE) has emerged as a promising clinical islet transplantation site because of its multiple advantages over the conventional intra-hepatic portal site. This includes reduced surgical invasiveness and increased islet graft survival rate. It also allows for enhanced ac...