Inhibition of NLRP3 inflammasome activation by cell-permeable stapled peptides

• Main Authors: Verma, Chandra Shekhar, Lane, David P., Mortellaro, Alessandra, Pal, Arumay, Neo, Kurt, Rajamani, Lakshminarayanan, Ferrer, Fernando Jose
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2019
• Subjects: DRNTU::Science::Biological sciences; Molecular Modelling; Inflammasome
• Online Access: https://hdl.handle.net/10356/85928; http://hdl.handle.net/10220/48277
• Institution: Nanyang Technological University

Interleukin-1β (IL-1β) is a major cytokine that initiates and enhances inflammatory responses. Excessive IL-1β production is a characteristic of most chronic inflammatory diseases, including atherosclerosis, type 2 diabetes, and obesity, which affect a large proportion of the global population. The...