Myogenic differentiation depends on the interplay of Grb2 and N-WASP

• Main Authors: Mitra, Payal, Thanabalu, Thirumaran
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2017
• Subjects: Myogenesis; N-WASP
• Online Access: https://hdl.handle.net/10356/86059; http://hdl.handle.net/10220/43927
• Institution: Nanyang Technological University

Myogenesis requires a well-coordinated withdrawal from cell cycle, morphological changes and cell fusion mediated by actin cytoskeleton. Grb2 is an adaptor protein whose central SH2 domain binds to phosphorylated tyrosine residues of activated receptors and activates intracellular signaling pathway,...