Reduced intracellular c-di-GMP content increases expression of quorum sensing-regulated genes in pseudomonas aeruginosa

• Main Authors: Chua, Song Lin, Liu, Yang, Li, Yingying, Ting, Hui Jun, Kohli, Gurjeet S., Cai, Zhao, Suwanchaikasem, Pipob, Goh, Kelvin Kau Kit, Ng, Sean Pin, Tolker-Nielsen, Tim, Yang, Liang, Givskov, Michael
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2018
• Subjects: Pseudomonas Aeruginosa; Cyclic-di-GMP
• Online Access: https://hdl.handle.net/10356/86095; http://hdl.handle.net/10220/45378
• Institution: Nanyang Technological University

Cyclic-di-GMP (c-di-GMP) is an intracellular secondary messenger which controls the biofilm life cycle in many bacterial species. High intracellular c-di-GMP content enhances biofilm formation via the reduction of motility and production of biofilm matrix, while low c-di-GMP content in biofilm cells...