Mesenchymal stem cell secretome improves tendon cell viability in vitro and tendon-bone healing in vivo when a tissue engineering strategy is used in a rat model of chronic massive rotator cuff tear

• Main Authors: Sevivas, Nuno, Teixeira, Fábio Gabriel, Portugal, Raquel, Direito-Santos, Bruno, Espregueira-Mendes, João, Oliveira, Filipe J., Silva, Rui F., Sousa, Nuno, Sow, Wan Ting, Nguyen, Luong T.H., Ng, Kee Woei, Salgado, António J.
• Other Authors: School of Materials Science & Engineering
• Format: Article
• Language: English
• Published: 2019
• Subjects: Engineering::Materials; Massive Rotator Cuff Tear; hMSC Secretome
• Online Access: https://hdl.handle.net/10356/86105; http://hdl.handle.net/10220/49260
• Institution: Nanyang Technological University

Background: Massive rotator cuff tears (MRCTs) represent a major clinical concern, especially when degeneration and chronicity are involved, which highly compromise healing capacity. Purpose: To study the effect of the secretome of mesenchymal stem cells (MSCs) on tendon cells (TCs) followed by the...