Microglial SMAD4 regulated by microRNA-146a promotes migration of microglia which support tumor progression in a glioma environment

• Main Authors: Dheen, S. Thameem, Karthikeyan, Aparna, Gupta, Neelima, Tang, Carol, Mallilankaraman, Karthik, Silambarasan, Maskomani, Shi, Meng, Lu, Lei, Ang, Beng Ti, Ling, Eng-Ang
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2018
• Subjects: Microglia; Glioma
• Online Access: https://hdl.handle.net/10356/86293; http://hdl.handle.net/10220/45234
• Institution: Nanyang Technological University

Glioma tumors constitute a significant portion of microglial cells, which are known to support tumor progression. The present study demonstrates that transforming growth factor-β (TGFβ) signaling pathway in microglia in a glioma environment is involved in tumor progression and pathogenesis. It has b...