Viral and antibody kinetics, and mosquito infectivity of an imported case of Zika fever due to Asian genotype (American strain) in Singapore

Viral and antibody kinetics, and mosquito infectivity of an imported case of Zika fever due to Asian genotype (American strain) in Singapore

We report a case of a Singaporean who acquired Zika virus (ZIKV) during a visit to Cuba. The infection was confirmed using molecular and serological methods. This report highlights potential drawbacks of using IgG serology for diagnosis of flavivirus infections in endemic regions. The low viremia de...

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Bibliographic Details
Main Authors: Tan, Cheong Huat, Tan, Li Kiang, Hapuarachchi, Hapuarachchige Chanditha, Lai, Yee Ling, Wong, Pei Sze Jeslyn, Mak, Keng Wai, Yap, Grace, Wong, Wing Yan, Leo, Yee Sin, Wong, Mei Chun, Ng, Lee Ching
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2018
Subjects:
Zika Virus
Antibody
Online Access:https://hdl.handle.net/10356/86306
http://hdl.handle.net/10220/45231
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Institution: Nanyang Technological University
Language: English
Description
Summary:We report a case of a Singaporean who acquired Zika virus (ZIKV) during a visit to Cuba. The infection was confirmed using molecular and serological methods. This report highlights potential drawbacks of using IgG serology for diagnosis of flavivirus infections in endemic regions. The low viremia detected during the early phase of this case resulted in low mosquito infectivity rates, suggesting the possibility of ZIKV transmission prior to clinical onset. The report also emphasizes the challenges of public health interventions for Zika fever and the importance of sustaining a low vector population to reduce the risk of arbovirus transmission in vulnerable regions.

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