In vivo studies of transdermal nanoparticle delivery with microneedle using photoacoustic microscopy
Microneedle technology allows micron-sized conduits to be formed within the outermost skin layers for both localized and systemic delivery of therapeutics including nanoparticles. Histological methods are often employed for characterization, and unfortunately do not allow for the in vivo visualizati...
Saved in:
Main Authors: | , , , |
---|---|
Other Authors: | |
Format: | Article |
Language: | English |
Published: |
2017
|
Subjects: | |
Online Access: | https://hdl.handle.net/10356/86332 http://hdl.handle.net/10220/44031 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Institution: | Nanyang Technological University |
Language: | English |
id |
sg-ntu-dr.10356-86332 |
---|---|
record_format |
dspace |
spelling |
sg-ntu-dr.10356-863322023-12-29T06:47:39Z In vivo studies of transdermal nanoparticle delivery with microneedle using photoacoustic microscopy Moothanchery, Mohesh Seeni, Razina Z. Xu, Chenjie Pramanik, Manojit School of Chemical and Biomedical Engineering Photoacoustic Imaging Photoacoustics Microneedle technology allows micron-sized conduits to be formed within the outermost skin layers for both localized and systemic delivery of therapeutics including nanoparticles. Histological methods are often employed for characterization, and unfortunately do not allow for the in vivo visualization of the delivery process. This study presents the utilization of optical resolution-photoacoustic microscopy to characterize the transdermal delivery of nanoparticles using microneedles. Specifically, we observe the in vivo transdermal delivery of gold nanoparticles using microneedles in mice ear and study the penetration, diffusion, and spatial distribution of the nanoparticles in the tissue. The promising results reveal that photoacoustic microscopy can be used as a potential imaging modality for the in vivo characterization of microneedles based drug delivery. Accepted version 2017-11-14T05:01:07Z 2019-12-06T16:20:34Z 2017-11-14T05:01:07Z 2019-12-06T16:20:34Z 2017 2017 Journal Article Moothanchery, M., Seeni, R. Z., Xu, C., & Pramanik, M. (2017). In vivo studies of transdermal nanoparticle delivery with microneedles using photoacoustic microscopy. Biomedical Optics Express, 8(12), 5483-5492. 2156-7085 https://hdl.handle.net/10356/86332 http://hdl.handle.net/10220/44031 10.1364/BOE.8.005483 202665 en Biomedical Optics Express © 2017 Optical Society of America. This is the author created version of a work that has been peer reviewed and accepted for publication by Biomedical Optics Express, Optical Society of America. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [https://doi.org/10.1364/BOE.8.005483]. 10 p. application/pdf |
institution |
Nanyang Technological University |
building |
NTU Library |
continent |
Asia |
country |
Singapore Singapore |
content_provider |
NTU Library |
collection |
DR-NTU |
language |
English |
topic |
Photoacoustic Imaging Photoacoustics |
spellingShingle |
Photoacoustic Imaging Photoacoustics Moothanchery, Mohesh Seeni, Razina Z. Xu, Chenjie Pramanik, Manojit In vivo studies of transdermal nanoparticle delivery with microneedle using photoacoustic microscopy |
description |
Microneedle technology allows micron-sized conduits to be formed within the outermost skin layers for both localized and systemic delivery of therapeutics including nanoparticles. Histological methods are often employed for characterization, and unfortunately do not allow for the in vivo visualization of the delivery process. This study presents the utilization of optical resolution-photoacoustic microscopy to characterize the transdermal delivery of nanoparticles using microneedles. Specifically, we observe the in vivo transdermal delivery of gold nanoparticles using microneedles in mice ear and study the penetration, diffusion, and spatial distribution of the nanoparticles in the tissue. The promising results reveal that photoacoustic microscopy can be used as a potential imaging modality for the in vivo characterization of microneedles based drug delivery. |
author2 |
School of Chemical and Biomedical Engineering |
author_facet |
School of Chemical and Biomedical Engineering Moothanchery, Mohesh Seeni, Razina Z. Xu, Chenjie Pramanik, Manojit |
format |
Article |
author |
Moothanchery, Mohesh Seeni, Razina Z. Xu, Chenjie Pramanik, Manojit |
author_sort |
Moothanchery, Mohesh |
title |
In vivo studies of transdermal nanoparticle delivery with microneedle using photoacoustic microscopy |
title_short |
In vivo studies of transdermal nanoparticle delivery with microneedle using photoacoustic microscopy |
title_full |
In vivo studies of transdermal nanoparticle delivery with microneedle using photoacoustic microscopy |
title_fullStr |
In vivo studies of transdermal nanoparticle delivery with microneedle using photoacoustic microscopy |
title_full_unstemmed |
In vivo studies of transdermal nanoparticle delivery with microneedle using photoacoustic microscopy |
title_sort |
in vivo studies of transdermal nanoparticle delivery with microneedle using photoacoustic microscopy |
publishDate |
2017 |
url |
https://hdl.handle.net/10356/86332 http://hdl.handle.net/10220/44031 |
_version_ |
1787136542875058176 |