Evaluating the role of puckering and fluorine atom in stability and folding of fluoroproline containing proteins

• Main Authors: Nadarajan, Saravanan Prabhu, Deepankumar, Kanagavel, Seo, Joo-Hyun, Yun, Hyungdon
• Other Authors: School of Materials Science & Engineering
• Format: Article
• Language: English
• Published: 2017
• Subjects: Enzyme stabilization; Fluorination
• Online Access: https://hdl.handle.net/10356/86479; http://hdl.handle.net/10220/44075
• Institution: Nanyang Technological University

In the past decade, numerous studies have been reported that the residue specific incorporation of fluorine containing analogs into protein can enhance the stability of protein. On the other hand, the incorporation of fluoroproline can enhance both stability and refolding rate of recombinant protein...