Evaluating the role of puckering and fluorine atom in stability and folding of fluoroproline containing proteins

• المؤلفون الرئيسيون: Nadarajan, Saravanan Prabhu, Deepankumar, Kanagavel, Seo, Joo-Hyun, Yun, Hyungdon
• مؤلفون آخرون: School of Materials Science & Engineering
• التنسيق: مقال
• اللغة: English
• منشور في: 2017
• الموضوعات: Enzyme stabilization; Fluorination
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/86479; http://hdl.handle.net/10220/44075

In the past decade, numerous studies have been reported that the residue specific incorporation of fluorine containing analogs into protein can enhance the stability of protein. On the other hand, the incorporation of fluoroproline can enhance both stability and refolding rate of recombinant protein...