The regulation of cellular responses to mechanical cues by Rho GTPases
The Rho GTPases regulate many cellular signaling cascades that modulate cell motility, migration, morphology and cell division. A large body of work has now delineated the biochemical cues and pathways, which stimulate the GTPases and their downstream effectors. However, cells also respond exquisite...
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sg-ntu-dr.10356-864942023-02-28T17:01:18Z The regulation of cellular responses to mechanical cues by Rho GTPases Hoon, Jing Ling Tan, Mei Hua Koh, Cheng-Gee School of Biological Sciences Matrix Stiffness Rho GTPases The Rho GTPases regulate many cellular signaling cascades that modulate cell motility, migration, morphology and cell division. A large body of work has now delineated the biochemical cues and pathways, which stimulate the GTPases and their downstream effectors. However, cells also respond exquisitely to biophysical and mechanical cues such as stiffness and topography of the extracellular matrix that profoundly influence cell migration, proliferation and differentiation. As these cellular responses are mediated by the actin cytoskeleton, an involvement of Rho GTPases in the transduction of such cues is not unexpected. In this review, we discuss an emerging role of Rho GTPase proteins in the regulation of the responses elicited by biophysical and mechanical stimuli. NRF (Natl Research Foundation, S’pore) MOE (Min. of Education, S’pore) Published version 2018-07-27T05:53:47Z 2019-12-06T16:23:17Z 2018-07-27T05:53:47Z 2019-12-06T16:23:17Z 2016 Journal Article Hoon, J. L., Tan, M. H., & Koh, C.-G. (2016). The regulation of cellular responses to mechanical cues by Rho GTPases. Cells, 5(2), 17-. 2073-4409 https://hdl.handle.net/10356/86494 http://hdl.handle.net/10220/45317 10.3390/cells5020017 27058559 en Cells © 2016 The Author(s); licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). 20 p. application/pdf |
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Nanyang Technological University |
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Asia |
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English |
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Matrix Stiffness Rho GTPases |
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Matrix Stiffness Rho GTPases Hoon, Jing Ling Tan, Mei Hua Koh, Cheng-Gee The regulation of cellular responses to mechanical cues by Rho GTPases |
| description |
The Rho GTPases regulate many cellular signaling cascades that modulate cell motility, migration, morphology and cell division. A large body of work has now delineated the biochemical cues and pathways, which stimulate the GTPases and their downstream effectors. However, cells also respond exquisitely to biophysical and mechanical cues such as stiffness and topography of the extracellular matrix that profoundly influence cell migration, proliferation and differentiation. As these cellular responses are mediated by the actin cytoskeleton, an involvement of Rho GTPases in the transduction of such cues is not unexpected. In this review, we discuss an emerging role of Rho GTPase proteins in the regulation of the responses elicited by biophysical and mechanical stimuli. |
| author2 |
School of Biological Sciences |
| author_facet |
School of Biological Sciences Hoon, Jing Ling Tan, Mei Hua Koh, Cheng-Gee |
| format |
Article |
| author |
Hoon, Jing Ling Tan, Mei Hua Koh, Cheng-Gee |
| author_sort |
Hoon, Jing Ling |
| title |
The regulation of cellular responses to mechanical cues by Rho GTPases |
| title_short |
The regulation of cellular responses to mechanical cues by Rho GTPases |
| title_full |
The regulation of cellular responses to mechanical cues by Rho GTPases |
| title_fullStr |
The regulation of cellular responses to mechanical cues by Rho GTPases |
| title_full_unstemmed |
The regulation of cellular responses to mechanical cues by Rho GTPases |
| title_sort |
regulation of cellular responses to mechanical cues by rho gtpases |
| publishDate |
2018 |
| url |
https://hdl.handle.net/10356/86494 http://hdl.handle.net/10220/45317 |
| _version_ |
1759856396687376384 |