Kinetics of Protein Aggregates Disposal by Aggrephagy

• Main Authors: Tan, S., Wong, Esther
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2017
• Subjects: Neurodegenerative Diseases; Ubiquitinated Protein Inclusions
• Online Access: https://hdl.handle.net/10356/86522; http://hdl.handle.net/10220/44055
• Institution: Nanyang Technological University

Macroautophagy has generated considerable interest because of its ability to recognize and target protein inclusions found prevalent in neurodegenerative diseases to lysosomes for elimination. Pharmacological upregulation of macroautophagy to remove disease-linked aggresomes has been reported to slo...