Elucidating the genomic architecture of Asian EGFR-mutant lung adenocarcinoma through multi-region exome sequencing
EGFR-mutant lung adenocarcinomas (LUAD) display diverse clinical trajectories and are characterized by rapid but short-lived responses to EGFR tyrosine kinase inhibitors (TKIs). Through sequencing of 79 spatially distinct regions from 16 early stage tumors, we show that despite low mutation burdens,...
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Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
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格式: | Article |
語言: | English |
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2018
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在線閱讀: | https://hdl.handle.net/10356/86558 http://hdl.handle.net/10220/45229 |
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