Shifting the gears of metabolic plasticity to drive cell state transitions in cancer

by Wu, Zhengwei, Lee, Yi Fei, Yeo, Xun Hui, Loo, Ser Yue, Tam, Wai Leong
Published 2021

Shifting the gears of metabolic plasticity to drive cell state transitions in cancer

by Wu, Zhengwei, Lee, Yi Fei, Yeo, Xun Hui, Loo, Ser Yue, Tam, Wai Leong
Published 2022

Histone variant H3.3 promotes metastasis in alveolar rhabdomyosarcoma.

by Karthik, Nandini, Lee, Jane Jia Hui, Soon, Joshua Ling Jun, Chiu, Hsin Yao, Loh, Amos Hong Pheng, Ong, Derrick Sek Tong, Tam, Wai Leong, Taneja, Reshma
Published 2023

Novel carfilzomib-based combinations as potential therapeutic strategies for liposarcomas

by Jeitany, Maya, Prabhu, Aishvaryaa, Dakle, Pushkar, Pathak, Elina, Madan, Vikas, Kanojia, Deepika, Mukundan, Vineeth, Jiang, Yan Yi, Landesman, Yosef, Tam, Wai Leong, Kappei, Dennis, Koeffler, H. Phillip
Published 2022

Theranostics application of tumor-initiating cell probe TiY in non-small cell lung cancer

by Lee, Yong-An, Lek, Jonathan Chee Chong, Rong, Gao, Wu, Zhengwei, Shathishwaran, S., Lee, Jane Jia Hui, Tam, Wai Leong, Wuestefeld, Torsten, Park, Sung-Jin, Jung, Sangyong, Kim, Beomsue, Kang, Nam-Young, Chang, Young-Tae
Published 2023

Signalling inhibition by ponatinib disrupts productive alternative lengthening of telomeres (ALT)

by Kusuma, Frances Karla, Prabhu, Aishvaryaa, Tieo, Galen, Syed Moiz Ahmed, Dakle, Pushkar, Yong, Wai Khang, Pathak, Elina, Madan, Vikas, Jiang, Yan Yi, Tam, Wai Leong, Kappei, Dennis, Dröge, Peter, Koeffler, H. Phillip, Jeitany, Maya
Published 2023

Robust delivery of RIG-I agonists using extracellular vesicles for anti-cancer immunotherapy

by Peng, Boya, Nguyen, Trinh Mai, Jayasinghe, Migara Kavishka, Gao, Chang, Pham, Thach Tuan, Vu, Luyen Tien, Yeo, Eric Yew Meng, Yap, Gracemary, Wang, Lingzhi, Goh, Boon Cher, Tam, Wai Leong, Luo, Dahai, Le, Minh TN
Published 2022

Rapid recruitment of p53 to DNA damage sites directs DNA repair choice and integrity

by Wang, Yu-Hsiu, Ho, Teresa L. F., Hariharan, Anushya, Goh, Hui Chin, Wong, Yao Liang, Verkaik, Nicole S., Lee, May Yin, Tam, Wai Leong, van Gent, Dik C., Venkitaraman, Ashok R., Sheetz, Michael P., Lane, David P.
Published 2022

A Runx1-enhancer Element eR1 Identified Lineage Restricted Mammary Luminal Stem Cells

by Matsuo, Junichi, Mon, Naing Naing, Douchi, Daisuke, Yamamura, Akihiro, Kulkarni, Madhura, Heng, Dede Liana, Chen, Sabirah, Nuttonmanit, Napat, Li, Ying, Yang, Henry, Lee, May Yin, Tam, Wai Leong, Osato, Motomi, Chuang, Linda Shyue Huey, Ito, Yoshiaki
Published 2022

The effect of inhibition of receptor tyrosine kinase AXL on DNA damage response in ovarian cancer

by Yeo, Xun Hui, Sundararajan, Vignesh, Wu, Zhengwei, Phua, Cheryl Zi Jin, Ho, Yin Ying, Peh, Esther Kai Lay, Chiu, Yi-Chia, Tan, Tuan Zea, Kappei, Dennis, Ho, Ying Swan, Tan, David Shao Peng, Tam, Wai Leong, Huang, Ruby Yun-Ju
Published 2023

The effect of inhibition of receptor tyrosine kinase AXL on DNA damage response in ovarian cancer

by Yeo, Xun Hui, Sundararajan, Vignesh, Wu, Zhengwei, Phua, Zi Jin Cheryl, Ho, Yin Ying, Peh, Kai Lay Esther, Chiu, Yi-Chia, Tan, Tuan Zea, Kappei, Dennis, Ho, Ying Swan, Tan, David Shao Peng, Tam, Wai Leong, Huang, Ruby Yun-Ju
Published 2023

Methionine is a metabolic dependency of tumor-initiating cells

by Wang, Zhenxun, Yip, Lian Yee, Lee, Jane Jia Hui, Wu, Zhengwei, Chew, Hui Yi, Chong, William Pooi Kiat, Teo, Chin Chye, Ang, Heather Yin-Kuan, Peh, Esther Kai Lay, Yuan, Ju, Ma, Siming, Choo, Kimberly Li Shi, Basri, Nurhidayah, Jiang, Xia, Yu, Qiang, Hillmer, Axel M., Lim, Wan Teck, Lim, Tony Kiat Hon, Takano, Angela, Tan, Eng Huat, Tan, Daniel Shao Weng, Ho, Ying Swan, Lim, Bing, Tam, Wai Leong
Published 2021

Tumour-initiating cell-specific miR-1246 and miR-1290 expression converge to promote non-small cell lung cancer progression

by Zhang, Wen Cai, Chin, Tan Min, Yang, Henry, Nga, Min En, Lunny, Declan Patrick, Lim, Edwin Kok Hao, Sun, Li Li, Pang, Yin Huei, Leow, Yi Ning, Malusay, Shanneen Rossellini Y, Lim, Priscilla Xin Hui, Lee, Jeravan Zili, Tan, Benedict Jian Wei, Ng, Shyh-Chang, Lim, Elaine Hsuen, Lim, Wan Teck, Tan, Daniel Shao Weng, Tan, Eng Huat, Tai, Bee Choo, Soo, Ross Andrew, Tam, Wai Leong, Lim, Bing
Published 2022

Dependency of NELF-E-SLUG-KAT2B epigenetic axis in breast cancer carcinogenesis

by Zhang, Jieqiong, Hu, Zhenhua, Chung, Hwa Hwa, Tian, Yun, Lau, Kah Weng, Ser, Zheng, Lim, Yan Ting, Sobota, Radoslaw M., Leong, Hwei Fen, Chen, Benjamin Jieming, Yeo, Clarisse Jingyi, Tan, Shawn Ying Xuan, Kang, Jian, Tan, Dennis Eng Kiat, Sou, Ieng Fong, McClurg, Urszula Lucja, Lakshmanan, Manikandan, Vaiyapuri, Thamil Selvan, Raju, Anandhkumar, Wong, Esther Sook Miin, Tergaonkar, Vinay, Rajarethinam, Ravisankar, Pathak, Elina, Tam, Wai Leong, Tan, Ern Yu, Tee, Wee-Wei
Published 2023

Elucidating the genomic architecture of Asian EGFR-mutant lung adenocarcinoma through multi-region exome sequencing

by Nahar, Rahul, Zhai, Weiwei, Zhang, Tong, Takano, Angela, Khng, Alexis J., Lee, Yin Yeng, Liu, Xingliang, Lim, Chong Hee, Koh, Tina P. T., Aung, Zaw Win, Lim, Tony Kiat Hon, Veeravalli, Lavanya, Yuan, Ju, Teo, Audrey S. M., Chan, Cheryl X., Poh, Huay Mei, Chua, Ivan M. L., Liew, Audrey Ann, Lau, Dawn Ping Xi, Kwang, Xue Lin, Toh, Chee Keong, Lim, Wan-Teck, Lim, Bing, Tam, Wai Leong, Tan, Eng-Huat, Hillmer, Axel M., Tan, Daniel S. W.
Published 2018

Intratumoural immune heterogeneity as a hallmark of tumour evolution and progression in hepatocellular carcinoma

by Nguyen, Phuong HD, Ma, Siming, Phua, Cheryl ZJ, Kaya, Neslihan A, Lai, Hannah LH, Lim, Chun Jye, Lim, Jia Qi, Wasser, Martin, Lai, Liyun, Tam, Wai Leong, Lim, Tony KH, Wan, Wei Keat, Loh, Tracy, Leow, Wei Qiang, Pang, Yin Huei, Chan, Chung Yip, Lee, Ser Yee, Cheow, Peng Chung, Toh, Han Chong, Ginhoux, Florent, Iyer, Shridhar, Kow, Alfred WC, Young Dan, Yock, Chung, Alexander, Goh, Brian KP, Albani, Salvatore, Chow, Pierce KH, Zhai, Weiwei, Chew, Valerie
Published 2021

Domain-specific p53 mutants activate EGFR by distinct mechanisms exposing tissue-independent therapeutic vulnerabilities

by Ho, Teresa Lai Fong, Lee, May Yin, Goh, Hui Chin, Ng, Germaine Yi Ning, Lee, Jane Jia Hui, Kannan, Srinivasaraghavan, Lim, Yan Ting, Zhao, Tianyun, Lim, Edwin Kok Hao, Phua, Cheryl Zi Jin, Lee, Yi Fei, Lim, Rebecca Yi Xuan, Ng, Perry Jun Hao, Yuan, Ju, Chan, Dedrick Kok Hong, Lieske, Bettina, Chong, Choon Seng, Lee, Kuok Chung, Lum, Jeffrey, Cheong, Wai Kit, Yeoh, Khay Guan, Tan, Ker Kan, Sobota, Radoslaw M, Verma, Chandra S, Lane, David P, Tam, Wai Leong, Venkitaraman, Ashok R
Published 2023

Domain-specific p53 mutants activate EGFR by distinct mechanisms exposing tissue-independent therapeutic vulnerabilities

by Ho, Teresa Lai Fong, Lee, May Yin, Goh, Hui Chin, Ng, Germaine Yi Ning, Lee, Jane Jia Hui, Kannan, Srinivasaraghavan, Lim, Yan Ting, Zhao, Tianyun, Lim, Edwin Kok Hao, Phua, Cheryl Zi Jin, Lee, Yi Fei, Lim, Rebecca Yi Xuan, Ng, Perry Jun Hao, Yuan, Ju, Chan, Dedrick Kok Hong, Lieske, Bettina, Chong, Choon Seng, Lee, Kuok Chung, Lum, Jeffrey, Cheong, Wai Kit, Yeoh, Khay Guan, Tan, Ker Kan, Sobota, Radoslaw M, Verma, Chandra S, Lane, David P, Tam, Wai Leong, Venkitaraman, Ashok R
Published 2023

Fatty acid oxidation is a druggable gateway regulating cellular plasticity for driving metastasis in breast cancer

by Loo, Ser Yue, Toh, Li Ping, Xie, William Haowei, Pathak, Elina, Tan, Wilson, Ma, Siming, Lee, May Yin, Shatishwaran, S., Yeo, Joanna Zhen Zhen, Yuan, Ju, Ho, Yin Ying, Peh, Esther Kai Lay, Muniandy, Magendran, Torta, Federico, Chan, Jack, Tan, Tira J., Sim, Yirong, Tan, Veronique, Tan, Benita, Madhukumar, Preetha, Yong, Wei Sean, Ong, Kong Wee, Wong, Chow Yin, Tan, Puay Hoon, Yap, Yoon Sim, Deng, Lih-Wen, Dent, Rebecca, Foo, Roger, Wenk, Markus R., Lee, Soo Chin, Ho, Ying Swan, Lim, Elaine Hsuen, Tam, Wai Leong
Published 2022

Domain-specific p53 mutants activate EGFR by distinct mechanisms exposing tissue-independent therapeutic vulnerabilities

by Ho, Teresa Lai Fong, Lee, May Yin, Goh, Hui Chin, Ng, Germaine Yi Ning, Lee, Jane Jia Hui, Kannan, Srinivasaraghavan, Lim, Yan Ting, Zhao, Tianyun, Lim, Edwin Kok Hao, Phua, Cheryl Zi Jin, Lee, Yi Fei, Lim, Rebecca Yi Xuan, Ng, Perry Jun Hao, Yuan, Ju, Chan, Dedrick Kok Hong, Lieske, Bettina, Chong, Choon Seng, Lee, Kuok Chung, Lum, Jeffrey, Cheong, Wai Kit, Yeoh, Khay Guan, Tan, Ker Kan, Sobota, Radoslaw M., Verma, Chandra Shekhar, Lane, David P., Tam, Wai Leong, Venkitaraman, Ashok R.
Published 2023