Long-distance repression by human silencers: chromatin interactions and phase separation in silencers

by Zhang, Ying, See, Yi Xiang, Tergaonkar, Vinay, Fullwood, Melissa Jane
Published 2022

Emerging regulatory mechanisms of noncoding RNAs in topologically associating domains

by Yeo, Samuel Jianjie, Ying, Chen, Fullwood, Melissa Jane, Tergaonkar, Vinay
Published 2023

Mast cells: Therapeutic targets for COVID-19 and beyond

by Lam, Hiu Yan, Tergaonkar, Vinay, Kumar, Alan Prem, Ahn, Kwang Seok
Published 2023

Non-canonical roles of canonical telomere binding proteins in cancers

by Akincilar, Semih Can, Chan, Claire Hian Tzer, Ng, Qin Feng, Fidan, Kerem, Tergaonkar, Vinay
Published 2022

BRD4 isoforms have distinct roles in tumour progression and metastasis in rhabdomyosarcoma.

by Das, Dipanwita, Leung, Jia Yu, Balamurugan, Shivaranjani, Tergaonkar, Vinay, Loh, Amos Hong Pheng, Chiang, Cheng-Ming, Taneja, Reshma
Published 2024

A role of Agrin in maintaining the stability of vascular endothelial growth factor receptor-2 during tumor angiogenesis

by Njah, Kizito, Chakraborty, Sayan, Qiu, Beiying, Arumugam, Surender, Raju, Anandhkumar, Pobbati, Ajaybabu V., Lakshmanan, Manikandan, Tergaonkar, Vinay, Thibault, Guillaume, Wang, Xiaomeng, Hong, Wanjin
Published 2019

Three-dimensional aggregated spheroid model of hepatocellular carcinoma using a 96-pillar/well plate

by Lee, Sang-Yun, Teng, Yvonne, Son, Miseol, Ku, Bosung, Hwang, Hyun Ju, Tergaonkar, Vinay, Chow, Pierce Kah-Hoe, Lee, Dong Woo, Nam, Do-Hyun
Published 2022

High-dose drug heat map analysis for drug safety and efficacy in multi-spheroid brain normal cells and GBM patient-derived cells

by Lee, Sang-Yun, Teng, Yvonne, Son, Miseol, Ku, Bosung, Moon, Ho Sang, Tergaonkar, Vinay, Chow, Pierce Kah-Hoe, Lee, Dong Woo, Nam, Do-Hyun
Published 2022

Telomerase regulates MYC-driven oncogenesis independent of its reverse transcriptase activity

by Koh C.M., Khattar Ekta, Leow Shi Chi, Liu Chia Yi, Muller Julius, Ang Wei Xia, Li Yinghui, Franzoso Guido, Li Shang, Guccione Ernesto, Tergaonkar Vinay
Published 2016

Chromatin interaction neural network (ChINN) : a machine learning-based method for predicting chromatin interactions from DNA sequences

by Cao, Fan, Zhang, Yu, Cai, Yichao, Animesh, Sambhavi, Zhang, Ying, Akincilar, Semih Can, Loh, Yan Ping, Li, Xinya, Chng, Wee Joo, Tergaonkar, Vinay, Kwoh, Chee Keong, Fullwood, Melissa Jane
Published 2021

Chromatin interaction neural network (ChINN): a machine learning-based method for predicting chromatin interactions from DNA sequences

by Cao, Fan, Zhang, Yu, Cai, Yichao, Animesh, Sambhavi, Zhang, Ying, Akincilar, Semih Can, Loh, Yan Ping, Li, Xinya, Chng, Wee Joo, Tergaonkar, Vinay, Kwoh, Chee Keong, Fullwood, Melissa J
Published 2021

GREB1 : an evolutionarily conserved protein with a glycosyltransferase domain links ERα glycosylation and stability to cancer

by Shin, Eun Myoung, Huynh, Vinh Thang, Neja, Sultan Abda, Liu, Chia Yi, Raju, Anandhkumar, Tan, Kelly, Tan, Nguan Soon, Gunaratne, Jayantha, Bi, Xuezhi, Iyer, Lakshminarayan M., Aravind, L., Tergaonkar, Vinay
Published 2021

H3K27me3-rich genomic regions can function as silencers to repress gene expression via chromatin interactions

by Cai, Yichao, Zhang, Ying, Loh, Yan Ping, Tng, Jia Qi, Lim, Mei Chee, Cao, Zhendong, Raju, Anandhkumar, Lieberman Aiden, Erez, Li, Shang, Manikandan, Lakshmanan, Tergaonkar, Vinay, Tucker-Kellogg, Greg, Fullwood, Melissa Jane
Published 2021

H3K27me3-rich genomic regions can function as silencers to repress gene expression via chromatin interactions

by Cai, Yichao, Zhang, Ying, Loh, Yan Ping, Tng, Jia Qi, Lim, Mei Chee, Cao, Zhendong, Raju, Anandhkumar, Lieberman Aiden, Erez, Li, Shang, Manikandan, Lakshmanan, Tergaonkar, Vinay, Tucker-Kellogg, Greg, Fullwood, Melissa Jane
Published 2022

Matriptase activation of gq drives epithelial disruption and inflammation via RSK and DUOX

by Ma, Jiajia, Scott, Claire A., Ho, Ying Na, Mahabaleshwar, Harsha, Marsay, Katherine S., Zhang, Changqing, Teow, Christopher Kj, Ng, Ser Sue, Zhang, Weibin, Tergaonkar, Vinay, Partridge, Lynda J., Roy, Sudipto, Amaya, Enrique, Carney, Tom J.
Published 2022

Thermal proximity coaggregation for system-wide profiling of protein complex dynamics in cells

by Tan, Chris Soon Heng, Go, Ka Diam, Bisteau, Xavier, Dai, Lingyun, Yong, Chern Han, Prabhu, Nayana, Ozturk, Mert Burak, Lim, Yan Ting, Sreekumar, Lekshmy, Lengqvist, Johan, Tergaonkar, Vinay, Kaldis, Philipp, Sobota, Radoslaw M., Nordlund, Pär
Published 2019

Matriptase activation of Gq drives epithelial disruption and inflammation via RSK and DUOX

by Ma, Jiajia, Scott, Claire A., Ho, Ying Na, Mahabaleshwar, Harsha, Marsay, Katherine S., Zhang, Changqing, Teow, Christopher K. J., Ng, Ser Sue, Zhang, Weibin, Tergaonkar, Vinay, Partridge, Lynda J., Roy, Sudipto, Amaya, Enrique, Carney, Tom J.
Published 2022

Identification of mechanism of cancer-cell-specific reactivation of hTERT offers therapeutic opportunities for blocking telomerase specifically in human colorectal cancer

by Akıncılar, Semih Can, Chua, Joelle Yi Heng, Ng, Qin Feng, Chan, Claire Hian Tzer, Eslami-S, Zahra, Chen, Kaijing, Low, Joo-Leng, Arumugam, Surendar, Aswad, Luay, Chua, Clarinda, Tan, Iain Beehuat, DasGupta, Ramanuj, Fullwood, Melissa Jane, Tergaonkar, Vinay
Published 2023

Super-silencer perturbation by EZH2 and REST inhibition leads to large loss of chromatin interactions and reduction in cancer growth

by Zhang, Ying, Chen, Kaijing, Tang, Seng Chuan, Cai, Yichao, Nambu, Akiko, See, Yi Xiang, Fu, Chaoyu, Raju, Anandhkumar, Lebeau, Benjamin, Ling, Zixun, Chan, Jia Jia, Tay, Yvonne, Mutwil, Marek, Lakshmanan, Manikandan, Tucker-Kellogg, Greg, Chng, Wee Joo, Tenen, Daniel G, Osato, Motomi, Tergaonkar, Vinay, Fullwood, Melissa Jane
Published 2024

HoxC5 and miR-615-3p target newly evolved genomic regions to repress hTERT and inhibit tumorigenesis

by Bi, Xuezhi, Muhammad Khairul Ramlee, Davies, James O.J., Yan, TingDong, Ooi, Wen Fong, Qamra, Aditi, Cheung, Alice, Ma, DongLiang, Sundaram, Gopinath Meenakshi, Xu, Chang, Xing, Manjie, Poon, LaiFong, Wang, Jing, Loh, Yan Ping, Ho, Jess Hui Jie, Ng, Joscelyn Jun Quan, Aswad, Luay, Rozen, Steve G., Ghosh, Sujoy, Bard, Frederic A., Sampath, Prabha, Tergaonkar, Vinay, Hughes, Jim R., Goh, Eyleen, Fullwood, Melissa Jane, Tan, Patrick, Li, Shang
Published 2018