H3K27me3-rich genomic regions can function as silencers to repress gene expression via chromatin interactions

• Main Authors: Cai, Yichao, Zhang, Ying, Loh, Yan Ping, Tng, Jia Qi, Lim, Mei Chee, Cao, Zhendong, Raju, Anandhkumar, Lieberman Aiden, Erez, Li, Shang, Manikandan, Lakshmanan, Tergaonkar, Vinay, Tucker-Kellogg, Greg, Fullwood, Melissa Jane
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Biological sciences::Molecular biology; Chromatin; Silencers
• Online Access: https://hdl.handle.net/10356/146349
• Institution: Nanyang Technological University

The mechanisms underlying gene repression and silencers are poorly understood. Here we investigate the hypothesis that H3K27me3-rich regions of the genome, defined from clusters of H3K27me3 peaks, may be used to identify silencers that can regulate gene expression via proximity or looping. We find t...