Super-silencer perturbation by EZH2 and REST inhibition leads to large loss of chromatin interactions and reduction in cancer growth

• المؤلفون الرئيسيون: Zhang, Ying, Chen, Kaijing, Tang, Seng Chuan, Cai, Yichao, Nambu, Akiko, See, Yi Xiang, Fu, Chaoyu, Raju, Anandhkumar, Lebeau, Benjamin, Ling, Zixun, Chan, Jia Jia, Tay, Yvonne, Mutwil, Marek, Lakshmanan, Manikandan, Tucker-Kellogg, Greg, Chng, Wee Joo, Tenen, Daniel G, Osato, Motomi, Tergaonkar, Vinay, Fullwood, Melissa Jane
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2024
• الموضوعات: Medicine, Health and Life Sciences; Chromatin structure; Gene silencing
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/180582

Human silencers have been shown to regulate developmental gene expression. However, the functional importance of human silencers needs to be elucidated, such as whether they can form 'super-silencers' and whether they are linked to cancer progression. Here, we show two silencer components...