Super-silencer perturbation by EZH2 and REST inhibition leads to large loss of chromatin interactions and reduction in cancer growth

• Main Authors: Zhang, Ying, Chen, Kaijing, Tang, Seng Chuan, Cai, Yichao, Nambu, Akiko, See, Yi Xiang, Fu, Chaoyu, Raju, Anandhkumar, Lebeau, Benjamin, Ling, Zixun, Chan, Jia Jia, Tay, Yvonne, Mutwil, Marek, Lakshmanan, Manikandan, Tucker-Kellogg, Greg, Chng, Wee Joo, Tenen, Daniel G, Osato, Motomi, Tergaonkar, Vinay, Fullwood, Melissa Jane
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2024
• Subjects: Medicine, Health and Life Sciences; Chromatin structure; Gene silencing
• Online Access: https://hdl.handle.net/10356/180582
• Institution: Nanyang Technological University

Human silencers have been shown to regulate developmental gene expression. However, the functional importance of human silencers needs to be elucidated, such as whether they can form 'super-silencers' and whether they are linked to cancer progression. Here, we show two silencer components...