MYC overexpression leads to increased chromatin interactions at superenhancers and MYC binding sites

• Main Authors: See, Yi Xiang, Chen, Kaijing, Fullwood, Melissa Jane
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Biological sciences::Genetics; Science::Biological sciences::Molecular biology; Chromatin Interactions; Cancer
• Online Access: https://hdl.handle.net/10356/155129
• Institution: Nanyang Technological University

The MYC oncogene encodes for the MYC protein and is frequently dysregulated across multiple cancer cell types, making it an attractive target for cancer therapy. MYC overexpression leads to MYC binding at active enhancers, resulting in a global transcriptional amplification of active genes. Since...