MYC overexpression in cancer increases chromatin interactions at superenhancers and c-Myc binding sites

• Main Author: See, Yi Xiang
• Other Authors: Melissa Jane Fullwood
• Format: Thesis-Doctor of Philosophy
• Language: English
• Published: Nanyang Technological University 2022
• Subjects: Science::Biological sciences::Genetics; Science::Biological sciences::Molecular biology
• Online Access: https://hdl.handle.net/10356/154939
• Institution: Nanyang Technological University

The MYC oncogene encodes for the c-Myc protein and is frequently dysregulated across multiple cancer cell types, making it an attractive target for cancer therapy. There have been many difficulties in targeting c-Myc, due to its complex network of regulators and the unstructured nature of its protei...