HoxC5 and miR-615-3p target newly evolved genomic regions to repress hTERT and inhibit tumorigenesis

• Main Authors: Bi, Xuezhi, Muhammad Khairul Ramlee, Davies, James O.J., Yan, TingDong, Ooi, Wen Fong, Qamra, Aditi, Cheung, Alice, Ma, DongLiang, Sundaram, Gopinath Meenakshi, Xu, Chang, Xing, Manjie, Poon, LaiFong, Wang, Jing, Loh, Yan Ping, Ho, Jess Hui Jie, Ng, Joscelyn Jun Quan, Aswad, Luay, Rozen, Steve G., Ghosh, Sujoy, Bard, Frederic A., Sampath, Prabha, Tergaonkar, Vinay, Hughes, Jim R., Goh, Eyleen, Fullwood, Melissa Jane, Tan, Patrick, Li, Shang
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2018
• Subjects: Tumorigenesis; Genomic
• Online Access: https://hdl.handle.net/10356/86576; http://hdl.handle.net/10220/45228
• Institution: Nanyang Technological University

The repression of telomerase activity during cellular differentiation promotes replicative aging and functions as a physiological barrier for tumorigenesis in long-lived mammals, including humans. However, the underlying mechanisms remain largely unclear. Here we describe how miR-615-3p represses hT...