Rapid recruitment of p53 to DNA damage sites directs DNA repair choice and integrity

Rapid recruitment of p53 to DNA damage sites directs DNA repair choice and integrity

p53 is primarily known as a downstream transcriptional effector in the DNA damage-response cascade. We report that endogenous p53 rapidly accumulates at DNA damage sites within 2 s of UVA microirradiation. The kinetics of p53 recruitment mimics those of known DNA damage-response proteins, such as Ku...

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Bibliographic Details
Main Authors: Wang, Yu-Hsiu, Ho, Teresa L. F., Hariharan, Anushya, Goh, Hui Chin, Wong, Yao Liang, Verkaik, Nicole S., Lee, May Yin, Tam, Wai Leong, van Gent, Dik C., Venkitaraman, Ashok R., Sheetz, Michael P., Lane, David P.
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2022
Subjects:
Science::Biological sciences
P53
Tumor Suppression
Online Access:https://hdl.handle.net/10356/162569
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Institution: Nanyang Technological University
Language: English

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https://hdl.handle.net/10356/162569

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