Rapid recruitment of p53 to DNA damage sites directs DNA repair choice and integrity

• Main Authors: Wang, Yu-Hsiu, Ho, Teresa L. F., Hariharan, Anushya, Goh, Hui Chin, Wong, Yao Liang, Verkaik, Nicole S., Lee, May Yin, Tam, Wai Leong, van Gent, Dik C., Venkitaraman, Ashok R., Sheetz, Michael P., Lane, David P.
• 其他作者: School of Biological Sciences
• 格式: Article
• 語言: English
• 出版: 2022
• 主題: Science::Biological sciences; P53; Tumor Suppression
• 在線閱讀: https://hdl.handle.net/10356/162569
• 機構: Nanyang Technological University

p53 is primarily known as a downstream transcriptional effector in the DNA damage-response cascade. We report that endogenous p53 rapidly accumulates at DNA damage sites within 2 s of UVA microirradiation. The kinetics of p53 recruitment mimics those of known DNA damage-response proteins, such as Ku...