THZ531 Induces a State of BRCAness in Multiple Myeloma Cells: Synthetic Lethality with Combination Treatment of THZ 531 with DNA Repair Inhibitors

by Shyamsunder, Pavithra, Sridharan, Shree Pooja, Madan, Vikas, Dakle, Pushkar, Zeya, Cao, Kanojia, Deepika, Chng, Wee-Joo, Ong, S Tiong, Koeffler, H Phillip
Published 2022

Novel carfilzomib-based combinations as potential therapeutic strategies for liposarcomas

by Jeitany, Maya, Prabhu, Aishvaryaa, Dakle, Pushkar, Pathak, Elina, Madan, Vikas, Kanojia, Deepika, Mukundan, Vineeth, Jiang, Yan Yi, Landesman, Yosef, Tam, Wai Leong, Kappei, Dennis, Koeffler, H. Phillip
Published 2022

Identification of a Novel CEBPE Enhancer Essential for Granulocytic Differentiation

by Shyamsunder, Pavithra, Shanmugasundaram, Mahalakshmi, Mayakonda, Anand, Teoh, Weoi Woon, Han, Lin, Lim, Mei Chee, Fullwood, Melissa, An, Omer, Yang, Henry, Shi, Jizhong, Hossain, Md Zakhir, Madan, Vikas, Koeffler, H Phillip
Published 2019

Identification of a novel enhancer of CEBPE essential for granulocytic differentiation.

by Shyamsunder, Pavithra, Shanmugasundaram, Mahalakshmi, Mayakonda, Anand, Dakle, Pushkar, Teoh, Weoi Woon, Han, Lin, Kanojia, Deepika, Lim, Mei Chee, Fullwood, Melissa, An, Omer, Yang, Henry, Jizhong, Shi, Hossain, Md Zakir, Madan, Vikas, Koeffler, H Phillip
Published 2019

Signalling inhibition by ponatinib disrupts productive alternative lengthening of telomeres (ALT)

by Kusuma, Frances Karla, Prabhu, Aishvaryaa, Tieo, Galen, Syed Moiz Ahmed, Dakle, Pushkar, Yong, Wai Khang, Pathak, Elina, Madan, Vikas, Jiang, Yan Yi, Tam, Wai Leong, Kappei, Dennis, Dröge, Peter, Koeffler, H. Phillip, Jeitany, Maya
Published 2023

ZRSR1 co-operates with ZRSR2 in regulating splicing of U12-type introns in murine hematopoietic cells

by Madan, Vikas, Cao, Zeya, Teoh, Weoi Woon, Dakle, Pushkar, Han, Lin, Shyamsunder, Pavithra, Jeitany, Maya, Zhou, Siqin, Li, Jia, Hazimah Mohd Nordin, Shi, JiZhong, Yu, Shuizhou, Yang, Henry, Md Zakir Hossain, Chng, Wee Joo, Koeffler, H Phillip
Published 2022

MNK1 and MNK2 enforce expression of E2F1, FOXM1, and WEE1 to drive soft tissue sarcoma

by Ke, Xin-Yu, Chen, Ye, Tham, Valarie Yu-Yan, Lin, Ruby Yu-Tong, Dakle, Pushkar, Nacro, Kassoum, Puhaindran, Mark Edward, Houghton, Peter, Pang, Angela, Lee, Victor Kwanmin, Ding, Ling-Wen, Gery, Sigal, Hill, Jeffrey, Chen, Leilei, Xu, Liang, Koeffler, H Phillip
Published 2021

Bromodomain and extraterminal proteins foster the core transcriptional regulatory programs and confer vulnerability in liposarcoma

by CHEN YE, Xu, Liang, Anand Mayakonda Thippeswamy, Huang, Mo-Li, Kanojia, Deepika, Tan, Tuan Zea, DAKLE PUSHKAR PRAVIN, LIN YU-TONG, RUBY, Ke, Xin-Yu, Said, Jonathan W, Chen, Jianxiang, Gery, Sigal, Ding, L.-W., Jiang, Yan-Yi, Pang, Angela, MARK EDWARD PUHAINDRAN, Boon Cher Goh, Koeffler, H Phillip
Published 2021

Interplay and cooperation between SREBF1 and master transcription factors regulate lipid metabolism and tumor-promoting pathways in squamous cancer

by Li, Li-Yan, Yang, Qian, Jiang, Yan-Yi, Yang, Wei, Jiang, Yuan, Li, Xiang, Hazawa, Masaharu, Zhou, Bo, Huang, Guo-Wei, Xu, Xiu-E, Gery, Sigal, Zhang, Ying, Ding, Ling-Wen, Ho, Allen S., Zumsteg, Zachary S., Wang, Ming-Rong, Fullwood, Melissa J., Freedland, Stephen J., Meltzer, Stephen J., Xu, Li-Yan, Li, En-Min, Koeffler, H. Phillip, Lin, De-Chen
Published 2022

Super-enhancer-driven long non-coding RNA LINC01503, regulated by TP63, is over-expressed and oncogenic in squamous cell carcinoma

by Xie, Jian-Jun, Jiang, Yan-Yi, Jiang, Yuan, Li, Chun-Quan, Lim, Mei-Chee, An, Omer, Mayakonda, Anand, Ding, Ling-Wen, Long, Lin, Sun, Chun, Lin, Le-Hang, Chen, Li, Wu, Jian-Yi, Wu, Zhi-Yong, Cao, Qi, Fang, Wang-Kai, Yang, Wei, Soukiasian, Harmik, Meltzer, Stephen J., Yang, Henry, Fullwood, Melissa, Xu, Li-Yan, Li, En-Min, Lin, De-Chen, Koeffler, H. Phillip
Published 2019

Super-Enhancer-Driven Long Non-Coding RNA LINC01503, Regulated by TP63, Is Over-Expressed and Oncogenic in Squamous Cell Carcinoma

by Xie, Jian-Jun, Jiang, Yan-Yi, Jiang, Yuan, Li, Chun-Quan, Lim, Mei-Chee, An, Omer, Mayakonda, Anand, Ding, Ling-Wen, Long, Lin, Sun, Chun, Lin, Le-Hang, Chen, Li, Wu, Jian-Yi, Wu, Zhi-Yong, Cao, Qi, Fang, Wang-Kai, Yang, Wei, Soukiasian, Harmik, Meltzer, Stephen J, Yang, Henry, Fullwood, Melissa, Xu, Li-Yan, Li, En-Min, Lin, De-Chen, Koeffler, H Phillip
Published 2019

Topography of transcriptionally active chromatin in glioblastoma

by Xu, Liang, Chen, Ye, Huang, Yulun, Sandanaraj, Edwin, Yu, John S., Lin, Ruby Yu-Tong, Dakle, Pushkar, Ke, Xin-Yu, Chong, Yuk Kien, Koh, Lynnette, Mayakonda, Anand, Nacro, Kassoum, Hill, Jeffrey, Huang, Mo-Li, Gery, Sigal, Lim, See Wee, Huang, Zhengyun, Xu, Ying, Chen, Jianxiang, Bai, Longchuan, Wang, Shaomeng, Wakimoto, Hiroaki, Yeo, Tseng Tsai, Ang, Beng Ti, Müschen, Markus, Tang, Carol, Tan, Tuan Zea, Koeffler, H. Phillip
Published 2021

A common MET polymorphism harnesses HER2 signaling to drive aggressive squamous cell carcinoma

by Kong, Li Ren, Salleh, Nur Afiqah Binte Mohamed, Ong, Richard Weijie, Tan, Tuan Zea, Syn, Nicholas L, Goh, Robby Miguel, Fhu, Chee Wei, Tan, Daniel SW, Iyer, N Gopalakrishna, Kannan, Srinivasaraghavan, Verma, Chandra S, Lim, Yaw Chyn, Soo, Ross, Ho, Jingshan, Huang, Yiqing, Lim, Joline SJ, Yan, Benedict Junrong, Nga, Min En, Lim, Seng Gee, Koeffler, H Phillip, Lee, Soo Chin, Kappei, Dennis, Hung, Huynh The, Goh, Boon Cher
Published 2020

Developmental analysis of bone marrow neutrophils reveals populations specialized in expansion, trafficking, and effector functions

by Kwok, Immanuel Weng Han, Leong, Penny Hweixian, Evrard, Maximilien, Chong, Shu Zhen, Teng, Karen W.W., Becht, Etienne, Chen, Jinmiao, Sieow, Je Lin, Ching, Goh Chi, Devi, Sapna, Adrover, José Maria, Li, Jackson L.Y., Liong, Ka Hang, Tan, Leonard, Poon, Zhiyong, Foo, Shihui, Chua, Jia Wang, Su, I-Hsin, Balabanian, Karl, Bachelerie, Françoise, Biswas, Subhra K., Larbi, Anis, Hwang, William Y.K., Madan, Vikas, Koeffler, H. Phillip, Wong, Siew Cheng, Newell, Evan W., Hidalgo, Andrés, Ginhoux, Florent, Ng, Lai Guan
Published 2019