Profiling of 3D genome organization in nasopharyngeal cancer needle biopsy patient samples by a modified Hi-C approach

by Animesh, Sambhavi, Choudhary, Ruchi, Wong, Bertrand Jern Han, Koh, Charlotte Tze Jia, Ng, Xin Yi, Tay, Joshua Kai Xun, Chong, Wan-Qin, Jian, Han, Chen, Leilei, Goh, Boon Cher, Fullwood, Melissa Jane
Published 2022

Profiling of 3D Genome Organization in Nasopharyngeal Cancer Needle Biopsy Patient Samples by a Modified Hi-C Approach

by Animesh, Sambhavi, Choudhary, Ruchi, Wong, Bertrand Jern Han, Koh, Charlotte Tze Jia, Ng, Xin Yi, Tay, Joshua Kai Xun, Chong, Wan-Qin, Jian, Han, Chen, Leilei, Goh, Boon Cher, Fullwood, Melissa Jane
Published 2022

Cis- and trans-regulations of pre-mRNA splicing by RNA editing enzymes influence cancer development

by Tang, Sze Jing, Shen, Haoqing, An, Omer, Hong, HuiQi, Li, Jia, Song, Yangyang, Han, Jian, Tay, Daryl Jin Tai, Ng, Vanessa Hui En, Bellido Molias, Fernando, Leong, Ka Wai, Pitcheshwar, Priyankaa, Yang, Henry, Chen, Leilei
Published 2020

Bidirectional regulation of adenosine-to-inosine (A-to-I) RNA editing by DEAH box helicase 9 (DHX9) in cancer

by Hong, HuiQi, An, Omer, Chan, Tim HM, Ng, Vanessa HE, Kwok, Hui Si, Lin, Jaymie S, Qi, Lihua, Han, Jian, Tay, Daryl JT, Tang, Sze Jing, Yang, Henry, Song, Yangyang, Molias, Fernando Bellido, Tenen, Daniel G, Chen, Leilei
Published 2019

MNK1 and MNK2 enforce expression of E2F1, FOXM1, and WEE1 to drive soft tissue sarcoma

by Ke, Xin-Yu, Chen, Ye, Tham, Valarie Yu-Yan, Lin, Ruby Yu-Tong, Dakle, Pushkar, Nacro, Kassoum, Puhaindran, Mark Edward, Houghton, Peter, Pang, Angela, Lee, Victor Kwanmin, Ding, Ling-Wen, Gery, Sigal, Hill, Jeffrey, Chen, Leilei, Xu, Liang, Koeffler, H Phillip
Published 2021

Suppression of adenosine-to-inosine (A-to-I) RNA editome by death associated protein 3 (DAP3) promotes cancer progression

by Han, Jian, An, Omer, Hong, HuiQi, Chan, Tim Hon Man, Song, Yangyang, Shen, Haoqing, Tang, Sze Jing, Lin, Jaymie Siqi, Ng, Vanessa Hui En, Tay, Daryl Jin Tai, Molias, Fernando Bellido, Pitcheshwar, Priyankaa, Tan, Hui Qing, Yang, Henry, Chen, Leilei
Published 2020

"3G" Trial: An RNA Editing Signature to Guide Gastric Cancer Chemotherapy

by An, Omer, Song, Yangyang, Ke, Xinyu, So, Jimmy Bok-Yan, Sundar, Raghav, Yang, Henry, Rha, Sun Young, Lee, Ming Hui, Tay, Su Ting, Ong, Xuewen, Tan, Angie Lay Keng, Ng, Matthew Chau Hsien, Tantoso, Erwin, Chen, Leilei, Tan, Patrick, Yong, Wei Peng
Published 2021

Aberrant hyperediting of the myeloma transcriptome by ADAR1 confers oncogenicity and is a marker of poor prognosis

by Teoh, Phaik Ju, An, Omer, Chung, Tae-Hoon, Chooi, Jing Yuan, Toh, Sabrina HM, Fan, Shuangyi, Wang, Wilson, Koh, Bryan TH, Fullwood, Melissa J, Ooi, Melissa G, de Mel, Sanjay, Soekojo, Cinnie Y, Chen, Leilei, Ng, Siok Bian, Yang, Henry, Chng, Wee Joo
Published 2019

RNA editing mediates the functional switch of COPA in a novel mechanism of hepatocarcinogenesis

by Song, Yangyang, An, Omer, Ren, Xi, Man Chan, Tim Hon, Tai Tay, Daryl Jin, Tang, Sze Jing, Han, Jian, Hong, HuiQi, En Ng, Vanessa Hui, Ke, Xinyu, Shen, Haoqing, Pitcheshwar, Priyankaa, Lin, Jaymie Siqi, Leong, Ka Wai, Molias, Fernando Bellido, Yang, Henry, Kappei, Dennis, Chen, Leilei
Published 2020

HNRNPM controls circRNA biogenesis and splicing fidelity to sustain cancer cell fitness

by Ho, Jessica S. Y., Di Tullio, Federico, Schwarz, Megan, Low, Diana, Incarnato, Danny, Gay, Florence, Tabaglio, Tommaso, Zhang, Jingxian, Wollmann, Heike, Chen, Leilei, An, Omer, Chan, Tim Hon Man, Hickman, Alexander Hall, Zheng, Simin, Roudko, Vladimir, Chen, Sujun, Karz, Alcida, Ahmed, Musaddeque, He, Hansen Housheng, Greenbaum, Benjamin D., Oliviero, Salvatore, Serresi, Michela, Gargiulo, Gaetano, Mann, Karen M., Hernando, Eva, Mulholland, David, Marazzi, Ivan, Wee, Dave Keng Boon, Guccione, Ernesto
Published 2022

Targeting RNA Editing of Antizyme Inhibitor 1: a Potential Oligonucleotide-Based Antisense Therapy for Cancer.

by Tai Tay, Daryl Jin, Song, Yangyang, Peng, Boya, Toh, Tan Boon, Hooi, Lissa, Kaixin Toh, Desiree-Faye, Hong, HuiQi, Tang, Sze Jing, Han, Jian, Gan, Wei Liang, Man Chan, Tim Hon, Krishna, Manchugondanahalli S, Patil, Kiran M, Maraswami, Manikantha, Loh, Teck Peng, Dan, Yock Young, Zhou, Lei, Bonney, Glenn Kunnath, Kah-Hoe Chow, Pierce, Chen, Gang, Kai-Hua Chow, Edward, Le, Minh Tn, Chen, Leilei
Published 2021

Red Blood Cell-Derived Extracellular Vesicles Display Endogenous Antiviral Effects and Enhance the Efficacy of Antiviral Oligonucleotide Therapy

by Jayasinghe, Migara K, Gao, Chang, Yap, Gracemary, Yeo, Brendon Zhi Jie, Vu, Luyen Tien, Tay, Douglas Jie Wen, Loh, Wen Xiu, Aw, Zhen Qin, Chen, Huixin, Phung, Dai Cao, Hoang, Dong Van, Prajogo, Rebecca Carissa, Hooi, Lissa, Lim, Fang Qing, Pirisinu, Marco, Mok, Chee Keng, Lim, Kah Wai, Tang, Sze Jing, Tan, Kai Sen, Chow, Edward Kai-Hua, Chen, Leilei, Phan, Anh Tuan, Chu, Justin Jang Hann, Le, Minh TN
Published 2024

Core-binding factor fusion downregulation of ADAR2 RNA editing contributes to AML leukemogenesis

by Guo, Mingrui, Chan, Tim Hon Man, Zhou, Qiling, An, Omer, Li, Ying, Song, Yangyang, Tan, Zi Hui, Ng, Vanessa Hui En, Peramangalam, Philomina Sona, Tan, Zhi Qing, Cao, Xinang, Iwanaga, Eisaku, Matsuoka, Masao, Ooi, Melissa G. M., Jen, Wei Ying, Koh, Liang Piu, Chan, Esther, Tan, Lip Kun, Goh, Yufen, Wang, Wilson, Koh, Bryan T. H., Chun, Chan Ming, Fullwood, Melissa Jane, Chng, Wee Joo, Osato, Motomi, Pulikkan, John Anto, Yang, Henry, Chen, Leilei, Tenen, Daniel G.
Published 2023

Pan-cancer pervasive upregulation of 3 ` UTR splicing drives tumourigenesis

by Chan, Jia Jia, Zhang, Bin, Chew, Xiao Hong, Salhi, Adil, Kwok, Zhi Hao, Lim, Chun You, Desi, Ng, Subramaniam, Nagavidya, Siemens, Angela, Kinanti, Tyas, Ong, Shane, Sanchez-Mejias, Avencia, Ly, Phuong Thao, An, Omer, Sundar, Raghav, Fan, Xiaonan, Wang, Shi, Siew, Bei En, Lee, Kuok Chung, Chong, Choon Seng, Lieske, Bettina, Cheong, Wai-Kit, Goh, Yufen, Fam, Wee Nih, Ooi, Melissa G., Koh, Bryan T. H., Iyer, Shridhar Ganpathi, Ling, Wen Huan, Chen, Jianbin, Yoong, Boon-Koon, Chanwat, Rawisak, Bonney, Glenn Kunnath, Goh, Brian K. P., Zhai, Weiwei, Fullwood, Melissa J., Wang, Wilson, Tan, Ker-Kan, Chng, Wee Joo, Dan, Yock Young, Pitt, Jason J., Roca, Xavier, Guccione, Ernesto, Vardy, Leah A., Chen, Leilei, Gao, Xin, Chow, Pierce K. H., Yang, Henry, Tay, Yvonne
Published 2022

Pan-cancer pervasive upregulation of 3 ' UTR splicing drives tumourigenesis

by Chan, Jia Jia, Zhang, Bin, Chew, Xiao Hong, Salhi, Adil, Kwok, Zhi Hao, Lim, Chun You, Desi, Ng, Subramaniam, Nagavidya, Siemens, Angela, Kinanti, Tyas, Ong, Shane, Sanchez-Mejias, Avencia, Ly, Phuong Thao, An, Omer, Sundar, Raghav, Fan, Xiaonan, Wang, Shi, Siew, Bei En, Lee, Kuok Chung, Chong, Choon Seng, Lieske, Bettina, Cheong, Wai-Kit, Goh, Yufen, Fam, Wee Nih, Ooi, Melissa G, Koh, Bryan TH, Iyer, Shridhar Ganpathi, Ling, Wen Huan, Chen, Jianbin, Yoong, Boon-Koon, Chanwat, Rawisak, Bonney, Glenn Kunnath, Goh, Brian KP, Zhai, Weiwei, Fullwood, Melissa J, Wang, Wilson, Tan, Ker-Kan, Chng, Wee Joo, Dan, Yock Young, Pitt, Jason J, Roca, Xavier, Guccione, Ernesto, Vardy, Leah A, Chen, Leilei, Gao, Xin, Chow, Pierce KH, Yang, Henry, Tay, Yvonne
Published 2022