Dual-targeting dual-action platinum(IV) platform for enhanced anticancer activity and reduced nephrotoxicity

by Babak, Maria V., Zhi, Yang, Czarny, Bertrand, Toh, Tan Boon, Hooi, Lissa, Chow, Edward Kai-Hua, Ang, Wee Han, Gibson, Dan, Pastorin, Giorgia
Published 2020

Rational drug combination design in patient-derived avatars reveals effective inhibition of hepatocellular carcinoma with proteasome and CDK inhibitors

by Lim, Jhin Jieh, Hooi, Lissa, Dan, Yock Young, Bonney, Glenn K, Zhou, Lei, Chow, Pierce K-H, Chee, Cheng Ean, Toh, Tan Boon, Chow, Edward K-H
Published 2023

Discovery of Broad-Spectrum Repurposed Drug Combinations Against Carbapenem-Resistant <i>Enterobacteriaceae</i> (CRE) Through Artificial Intelligence (AI)-Driven Platform

by Li, Ming, You, Kui, Wang, Peter, Hooi, Lissa, Chen, Yahua, Siah, Anqi, Tan, Shi-Bei, Teo, Jeanette, Ng, Oon-Tek, Marimuthu, Kalisvar, Venkatachalam, Indumathi, Blasiak, Agata, Chow, Edward Kai-Hua, Ho, Dean, Gan, Yunn-Hwen
Published 2024

IDentif.AI: Rapidly optimizing combination therapy design against severe Acute Respiratory Syndrome Coronavirus 2 (SARS-Cov-2) with digital drug development

by Blasiak, Agata, Lim, Jhin Jieh, Seah, Shirley Gek Kheng, Kee, Theodore, Remus, Alexandria, Chye, De Hoe, Wong, Pui San, Hooi, Lissa, Truong, Anh T. L., Le, Nguyen, Chan, Conrad E. Z., Desai, Rishi, Ding, Xianting, Hanson, Brendon J., Chow, Edward Kai-Hua, Ho, Dean
Published 2022

IDentif.AI: Rapidly optimizing combination therapy design against severe Acute Respiratory Syndrome Coronavirus 2 (SARS-Cov-2) with digital drug development

by Blasiak, Agata, Lim, Jhin Jieh, Seah, Shirley Gek Kheng, Kee, Theodore, Remus, Alexandria, Chye, De Hoe, Wong, Pui San, Hooi, Lissa, Truong, Anh TL, Le, Nguyen, Chan, Conrad EZ, Desai, Rishi, Ding, Xianting, Hanson, Brendon J, Chow, Edward Kai-Hua, Ho, Dean
Published 2023

Targeted inhibition of purine metabolism is effective in suppressing hepatocellular carcinoma progression

by Chong, Yong Chun, Toh, Tan Boon, Chan, Zhiling, Lin, Quy Xiao Xuan, Thng, Dexter Kai Hao, Hooi, Lissa, Ding, Zhaobing, Shuen, Timothy, Toh, Han Chong, Dan, Yock Young, Bonney, Glenn Kunnath, Zhou, Lei, Chow, Pierce, Wang, Yulan, Benoukraf, Touati, Chow, Edward Kai-Hua, Han, Weiping
Published 2020

IDentif.AI-Omicron: Harnessing an AI-Derived and Disease-Agnostic Platform to Pinpoint Combinatorial Therapies for Clinically Actionable Anti-SARS-CoV-2 Intervention

by Blasiak, Agata, Truong, Anh TL, Wang, Peter, Hooi, Lissa, Chye, De Hoe, Tan, Shi-Bei, You, Kui, Remus, Alexandria, Allen, David Michael, Chai, Louis Yi Ann, Chan, Conrad EZ, Lye, David CB, Tan, Gek-Yen G, Seah, Shirley GK, Chow, Edward Kai-Hua, Ho, Dean
Published 2022

A flexi-PEGDA upconversion implant for wireless brain photodynamic therapy

by Teh, Daniel Boon Loong, Bansal, Akshaya, Chai, Chou, Toh, Tan Boon, Tucker, Robert Alan Jappy, Gammad, Gil Gerald Lasam, Yeo, Yanzhuang, Lei, Zhendong, Zheng, Xiang, Yang, Fengyuan, Ho, John S., Bolem, Nagarjun, Wu, Bing Cheng, Gnanasammandhan, Muthu Kumar, Hooi, Lissa, Dawe, Gavin Stewart, Libedinsky, Camilo, Ong, Wei-Yi, Halliwell, Barry, Chow, Edward Kai-Hua, Lim, Kah-Leong, Zhang, Yong, Kennedy, Brian K.
Published 2022

The IDentif.AI-x pandemic readiness platform: rapid prioritization of optimized COVID-19 combination therapy regimens

by Blasiak, Agata, Truong, Anh T. L., Remus, Alexandria, Hooi, Lissa, Seah, Shirley Gek Kheng, Wang, Peter, Chye, De Hoe, Lim, Angeline Pei Chiew, Ng, Kim Tien, Teo, Swee Teng, Tan, Yee-Joo, Allen, David Michael, Chai, Louis Yi Ann, Chng, Wee Joo, Lin, Raymond T. P., Lye, David C., Wong, John Eu-Li, Tan, Gladys Gek-Yen, Chan, Conrad En Zuo, Chow, Edward Kai-Hua, Ho, Dean
Published 2023

Targeting RNA Editing of Antizyme Inhibitor 1: a Potential Oligonucleotide-Based Antisense Therapy for Cancer.

by Tai Tay, Daryl Jin, Song, Yangyang, Peng, Boya, Toh, Tan Boon, Hooi, Lissa, Kaixin Toh, Desiree-Faye, Hong, HuiQi, Tang, Sze Jing, Han, Jian, Gan, Wei Liang, Man Chan, Tim Hon, Krishna, Manchugondanahalli S, Patil, Kiran M, Maraswami, Manikantha, Loh, Teck Peng, Dan, Yock Young, Zhou, Lei, Bonney, Glenn Kunnath, Kah-Hoe Chow, Pierce, Chen, Gang, Kai-Hua Chow, Edward, Le, Minh Tn, Chen, Leilei
Published 2021

The IDentif.AI-x pandemic readiness platform: Rapid prioritization of optimized COVID-19 combination therapy regimens.

by Blasiak, Agata, Truong, Anh TL, Remus, Alexandria, Hooi, Lissa, Seah, Shirley Gek Kheng, Wang, Peter, Chye, De Hoe, Lim, Angeline Pei Chiew, Ng, Kim Tien, Teo, Swee Teng, Tan, Yee-Joo, Allen, David Michael, Chai, Louis Yi Ann, Chng, Wee Joo, Lin, Raymond TP, Lye, David CB, Wong, John Eu-Li, Tan, Gek-Yen Gladys, Chan, Conrad En Zuo, Chow, Edward Kai-Hua, Ho, Dean
Published 2022

Red Blood Cell-Derived Extracellular Vesicles Display Endogenous Antiviral Effects and Enhance the Efficacy of Antiviral Oligonucleotide Therapy

by Jayasinghe, Migara K, Gao, Chang, Yap, Gracemary, Yeo, Brendon Zhi Jie, Vu, Luyen Tien, Tay, Douglas Jie Wen, Loh, Wen Xiu, Aw, Zhen Qin, Chen, Huixin, Phung, Dai Cao, Hoang, Dong Van, Prajogo, Rebecca Carissa, Hooi, Lissa, Lim, Fang Qing, Pirisinu, Marco, Mok, Chee Keng, Lim, Kah Wai, Tang, Sze Jing, Tan, Kai Sen, Chow, Edward Kai-Hua, Chen, Leilei, Phan, Anh Tuan, Chu, Justin Jang Hann, Le, Minh TN
Published 2024