Dual-targeting dual-action platinum(IV) platform for enhanced anticancer activity and reduced nephrotoxicity

• المؤلفون الرئيسيون: Babak, Maria V., Zhi, Yang, Czarny, Bertrand, Toh, Tan Boon, Hooi, Lissa, Chow, Edward Kai-Hua, Ang, Wee Han, Gibson, Dan, Pastorin, Giorgia
• مؤلفون آخرون: School of Materials Science and Engineering
• التنسيق: مقال
• اللغة: English
• منشور في: 2020
• الموضوعات: Science::Medicine; Antitumor Agents; Drug Discovery
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/144107

A novel and highly efficient dual‐targeting platform was designed to ensure targeted in vivo delivery of dual‐action PtIV prodrugs. The dual targeting was established by liposomal encapsulation of PtIV complexes, thereby utilizing the enhanced permeability and retention (EPR) effect as the first sta...