Dual-targeting dual-action platinum(IV) platform for enhanced anticancer activity and reduced nephrotoxicity

Dual-targeting dual-action platinum(IV) platform for enhanced anticancer activity and reduced nephrotoxicity

A novel and highly efficient dual‐targeting platform was designed to ensure targeted in vivo delivery of dual‐action PtIV prodrugs. The dual targeting was established by liposomal encapsulation of PtIV complexes, thereby utilizing the enhanced permeability and retention (EPR) effect as the first sta...

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Bibliographic Details
Main Authors: Babak, Maria V., Zhi, Yang, Czarny, Bertrand, Toh, Tan Boon, Hooi, Lissa, Chow, Edward Kai-Hua, Ang, Wee Han, Gibson, Dan, Pastorin, Giorgia
Other Authors: School of Materials Science and Engineering
Format: Article
Language:English
Published: 2020
Subjects:
Science::Medicine
Antitumor Agents
Drug Discovery
Online Access:https://hdl.handle.net/10356/144107
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/144107

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