EPIGENETICS OF HEPATOCELLULAR CARCINOMA.

by Toh, Tan Boon, Lim, Jhin Jieh, Chow, Edward Kai-Hua
Published 2019

Capitalizing on Synthetic Lethality of MYC to Treat Cancer in the Digital Age

by Thng, Dexter Kai Hao, Toh, Tan Boon, Chow, Edward Kai-Hua
Published 2022

Improving the therapeutic ratio of radiotherapy against radioresistant cancers: Leveraging on novel artificial intelligence-based approaches for drug combination discovery

by Poon, Dennis Jun Jie, Tay, Li Min, Ho, Dean, Chua, Melvin Lee Kiang, Chow, Edward Kai-Hua, Yeo, Eugenia Li Ling
Published 2022

Dual-targeting dual-action platinum(IV) platform for enhanced anticancer activity and reduced nephrotoxicity

by Babak, Maria V., Zhi, Yang, Czarny, Bertrand, Toh, Tan Boon, Hooi, Lissa, Chow, Edward Kai-Hua, Ang, Wee Han, Gibson, Dan, Pastorin, Giorgia
Published 2020

Bioorthogonal Catalysis for Treatment of Solid Tumors Using Thermostable, Self-Assembling, Single Enzyme Nanoparticles and Natural Product Conversion with Indole-3-acetic Acid

by Sadeghi, Samira, Masurkar, Nihar D, Mavelli, Girish Vallerinteavide, Deshpande, Siddharth, Tan, Warren Kok Yong, Yee, Sherman, Kang, Shin-Ae, Lim, Yoon-Pin, Chow, Edward Kai-Hua, Drum, Chester L
Published 2022

Reciprocal interaction of wntand RXR-α pathways in hepatocyte development and hepatocellular carcinoma

by Li, Jinyu, Chanrion, Maïa, Sawey, Eric T., Wang, Tim, Chow, Edward Kai-Hua, Tward, Aaron D., Su, Yi, Xue, Wen, Lucito, Robert, Zender, Lars, Lowe, Scott W Scott W, Bishop, Jamie Michael, Powers, Scott
Published 2015

Discovery of Broad-Spectrum Repurposed Drug Combinations Against Carbapenem-Resistant <i>Enterobacteriaceae</i> (CRE) Through Artificial Intelligence (AI)-Driven Platform

by Li, Ming, You, Kui, Wang, Peter, Hooi, Lissa, Chen, Yahua, Siah, Anqi, Tan, Shi-Bei, Teo, Jeanette, Ng, Oon-Tek, Marimuthu, Kalisvar, Venkatachalam, Indumathi, Blasiak, Agata, Chow, Edward Kai-Hua, Ho, Dean, Gan, Yunn-Hwen
Published 2024

IDentif.AI: Rapidly optimizing combination therapy design against severe Acute Respiratory Syndrome Coronavirus 2 (SARS-Cov-2) with digital drug development

by Blasiak, Agata, Lim, Jhin Jieh, Seah, Shirley Gek Kheng, Kee, Theodore, Remus, Alexandria, Chye, De Hoe, Wong, Pui San, Hooi, Lissa, Truong, Anh T. L., Le, Nguyen, Chan, Conrad E. Z., Desai, Rishi, Ding, Xianting, Hanson, Brendon J., Chow, Edward Kai-Hua, Ho, Dean
Published 2022

IDentif.AI: Rapidly optimizing combination therapy design against severe Acute Respiratory Syndrome Coronavirus 2 (SARS-Cov-2) with digital drug development

by Blasiak, Agata, Lim, Jhin Jieh, Seah, Shirley Gek Kheng, Kee, Theodore, Remus, Alexandria, Chye, De Hoe, Wong, Pui San, Hooi, Lissa, Truong, Anh TL, Le, Nguyen, Chan, Conrad EZ, Desai, Rishi, Ding, Xianting, Hanson, Brendon J, Chow, Edward Kai-Hua, Ho, Dean
Published 2023

Targeted inhibition of purine metabolism is effective in suppressing hepatocellular carcinoma progression

by Chong, Yong Chun, Toh, Tan Boon, Chan, Zhiling, Lin, Quy Xiao Xuan, Thng, Dexter Kai Hao, Hooi, Lissa, Ding, Zhaobing, Shuen, Timothy, Toh, Han Chong, Dan, Yock Young, Bonney, Glenn Kunnath, Zhou, Lei, Chow, Pierce, Wang, Yulan, Benoukraf, Touati, Chow, Edward Kai-Hua, Han, Weiping
Published 2020

IDentif.AI-Omicron: Harnessing an AI-Derived and Disease-Agnostic Platform to Pinpoint Combinatorial Therapies for Clinically Actionable Anti-SARS-CoV-2 Intervention

by Blasiak, Agata, Truong, Anh TL, Wang, Peter, Hooi, Lissa, Chye, De Hoe, Tan, Shi-Bei, You, Kui, Remus, Alexandria, Allen, David Michael, Chai, Louis Yi Ann, Chan, Conrad EZ, Lye, David CB, Tan, Gek-Yen G, Seah, Shirley GK, Chow, Edward Kai-Hua, Ho, Dean
Published 2022

Whole-genome sequencing reveals potent therapeutic strategy for monomorphic epitheliotropic intestinal T-cell lymphoma

by Huang, Dachuan, Lim, Jing Quan, Cheah, Daryl Ming Zhe, Kahliab, Khalilatul Hanisah Binte Mohd, Laurensia, Yurike, Pang, Jane Wan Lu, Wong, Esther Kam Yin, Chia, Burton Kuan Hui, Goh, Jasmine, Zhang, Xiyun, Chan, Jason Yongsheng, Chow, Edward Kai-Hua, Tan, Soo Yong, Lim, Soon Thye, Ong, Choon Kiat
Published 2023

A flexi-PEGDA upconversion implant for wireless brain photodynamic therapy

by Teh, Daniel Boon Loong, Bansal, Akshaya, Chai, Chou, Toh, Tan Boon, Tucker, Robert Alan Jappy, Gammad, Gil Gerald Lasam, Yeo, Yanzhuang, Lei, Zhendong, Zheng, Xiang, Yang, Fengyuan, Ho, John S., Bolem, Nagarjun, Wu, Bing Cheng, Gnanasammandhan, Muthu Kumar, Hooi, Lissa, Dawe, Gavin Stewart, Libedinsky, Camilo, Ong, Wei-Yi, Halliwell, Barry, Chow, Edward Kai-Hua, Lim, Kah-Leong, Zhang, Yong, Kennedy, Brian K.
Published 2022

The IDentif.AI-x pandemic readiness platform: rapid prioritization of optimized COVID-19 combination therapy regimens

by Blasiak, Agata, Truong, Anh T. L., Remus, Alexandria, Hooi, Lissa, Seah, Shirley Gek Kheng, Wang, Peter, Chye, De Hoe, Lim, Angeline Pei Chiew, Ng, Kim Tien, Teo, Swee Teng, Tan, Yee-Joo, Allen, David Michael, Chai, Louis Yi Ann, Chng, Wee Joo, Lin, Raymond T. P., Lye, David C., Wong, John Eu-Li, Tan, Gladys Gek-Yen, Chan, Conrad En Zuo, Chow, Edward Kai-Hua, Ho, Dean
Published 2023

The IDentif.AI-x pandemic readiness platform: Rapid prioritization of optimized COVID-19 combination therapy regimens.

by Blasiak, Agata, Truong, Anh TL, Remus, Alexandria, Hooi, Lissa, Seah, Shirley Gek Kheng, Wang, Peter, Chye, De Hoe, Lim, Angeline Pei Chiew, Ng, Kim Tien, Teo, Swee Teng, Tan, Yee-Joo, Allen, David Michael, Chai, Louis Yi Ann, Chng, Wee Joo, Lin, Raymond TP, Lye, David CB, Wong, John Eu-Li, Tan, Gek-Yen Gladys, Chan, Conrad En Zuo, Chow, Edward Kai-Hua, Ho, Dean
Published 2022

A chemical biology approach reveals a dependency of glioblastoma on biotin distribution

by Yoon, Jeehyun, Grinchuk, Oleg V., Kannan, Srinivasaraghavan, Ang, Melgious Jin Yan, Li, Zhenglin, Tay, Emmy Xue Yun, Lok, Ker Zhing, Lee, Bernice Woon Li, Chuah, You Heng, Chia, Kimberly, Tirado-Magallanes, Roberto, Liu, Chenfei, Zhao, Haonan, Hor, Jin Hui, Lim, Jhin Jieh, Benoukraf, Touati, Toh, Tan Boon, Chow, Edward Kai-Hua, Kovalik, Jean-Paul, Ching, Jianhong, Ng, Shi-Yan, Koh, Ming Joo, Liu, Xiaogang, Verma, Chandra Shekhar, Ong, Derrick Sek Tong
Published 2022

Red Blood Cell-Derived Extracellular Vesicles Display Endogenous Antiviral Effects and Enhance the Efficacy of Antiviral Oligonucleotide Therapy

by Jayasinghe, Migara K, Gao, Chang, Yap, Gracemary, Yeo, Brendon Zhi Jie, Vu, Luyen Tien, Tay, Douglas Jie Wen, Loh, Wen Xiu, Aw, Zhen Qin, Chen, Huixin, Phung, Dai Cao, Hoang, Dong Van, Prajogo, Rebecca Carissa, Hooi, Lissa, Lim, Fang Qing, Pirisinu, Marco, Mok, Chee Keng, Lim, Kah Wai, Tang, Sze Jing, Tan, Kai Sen, Chow, Edward Kai-Hua, Chen, Leilei, Phan, Anh Tuan, Chu, Justin Jang Hann, Le, Minh TN
Published 2024