Cell envelope defects of different capsule-null mutants in K1 hypervirulent Klebsiella pneumoniae can affect bacterial pathogenesis

by Tan, Yi Han, Chen, Yahua, Chu, Wilson HW, Sham, Lok-To, Gan, Yunn-Hwen
Published 2022

Glutathione catabolism by Enterobacteriaceae species to hydrogen sulphide adversely affects the viability of host systems in the presence of 5 ' fluorodeoxyuridine

by Lim, Daniel Rui Xiang, Chen, Yahua, Ng, Li Fang, Gruber, Jan, Gan, Yunn-Hwen
Published 2023

Bacterial-induced cell fusion is a danger signal triggering cGAS-STING pathway via micronuclei formation

by Ku, Joanne Wei Kay, Chen, Yahua, Lim, Bryan Jian Wei, Gasser, Stephan, Crasta, Karen Carmelina, Gan, Yunn-Hwen
Published 2022

Acquisition of regulator on virulence plasmid of hypervirulent Klebsiella allows bacterial lifestyle switch in response to iron

by Chu, Wilson HW, Tan, Yi Han, Tan, Si Yin, Chen, Yahua, Yong, Melvin, Lye, David C, Kalimuddin, Shirin, Archuleta, Sophia, Gan, Yunn-Hwen
Published 2023

A hydrophilic polyimidazolium antibiotic targeting the membranes of Gram-negative bacteria

by Chen, Yahua, Yong, Melvin, Li, Ming, Si, Zhangyong, Koh, Chong Hui, Lau, Pearlyn, Chang, Yi Wei, Teo, Jeanette, Chan-Park, Mary B., Gan, Yunn-Hwen
Published 2024

A hydrophilic polyimidazolium antibiotic targeting the membranes of Gram-negative bacteria

by Chen, Yahua, Yong, Melvin, Li, Ming, Si, Zhangyong, Koh, Chong Hui, Lau, Pearlyn, Chang, Yi Wei, Teo, Jeanette, Chan-Park, Mary B, Gan, Yunn-Hwen
Published 2024

Extended loop region of Hcp1 is critical for the assembly and function of type VI secretion system in Burkholderia pseudomallei.

by Lim, Yan Ting, Jobichen, Chacko, Wong, Jocelyn, Direk Limmathurotsakul, ดิเรก ลิ้มมธุรสกุล, Li, Shaowei, Chen, Yahua, Raida, Manfred, Nalini Srinivasan, MacAry, Paul Anthony, Sivaraman, J., Gan, Yunn-Hwen
Published 2015

The proteobacterial species Burkholderia pseudomallei produces ergothioneine, which enhances virulence in mammalian infection

by Gamage, Akshamal M, Liao, Cangsong, Cheah, Irwin K, Chen, Yahua, Lim, Daniel RX, Ku, Joanne WK, Chee, Rhonda Sin Ling, Gengenbacher, Martin, Seebeck, Florian P, Halliwell, Barry, Gan, Yunn-Hwen
Published 2023

Discovery of Broad-Spectrum Repurposed Drug Combinations Against Carbapenem-Resistant <i>Enterobacteriaceae</i> (CRE) Through Artificial Intelligence (AI)-Driven Platform

by Li, Ming, You, Kui, Wang, Peter, Hooi, Lissa, Chen, Yahua, Siah, Anqi, Tan, Shi-Bei, Teo, Jeanette, Ng, Oon-Tek, Marimuthu, Kalisvar, Venkatachalam, Indumathi, Blasiak, Agata, Chow, Edward Kai-Hua, Ho, Dean, Gan, Yunn-Hwen
Published 2024

Acquisition of plasmid with carbapenem-resistance gene blaKPC2 in hypervirulent Klebsiella pneumoniae, Singapore

by Chen, Yahua, Marimuthu, Kalisvar, Teo, Jeanette, Venkatachalam, Indumathi, Cherng, Benjamin Pei Zhi, Wang, Liang De, Prakki, Sai Rama Sridatta, Xu, Weizhen, Tan, Yi Han, Nguyen, Lan Chi, Koh, Tse Hsien, Ng, Oon Tek, Gan, Yunn-Hwen
Published 2020

Dominant CarbapenemaseEncoding Plasmids in Clinical Enterobacterales Isolates and Hypervirulent Klebsiella pneumoniae, Singapore

by Yong, Melvin, Chen, Yahua, Oo, Guodong, Chang, Kai Chirng, Chu, Wilson HW, Teo, Jeanette, Venkatachalam, Indumathi, Thevasagayam, Natascha May, Sridatta, Prakki S Rama, Koh, Vanessa, Marcoleta, Andres E, Chen, Hanrong, Nagarajan, Niranjan, Kalisvar, Marimuthu, Ng, Oon Tek, Gan, Yunn-Hwen
Published 2023

Designer broad-spectrum polyimidazolium antibiotics

by Zhong, Wenbin, Shi, Zhenyu, Mahadevegowda, Surendra H., Liu, Bo, Zhang, Kaixi, Koh, Chong Hui, Ruan, Lin, Chen, Yahua, Zeden, Merve S., Pee, Carmen J. E., Marimuthu, Kalisvar, De, Partha Pratim, Ng, Oon Tek, Zhu, Yabin, Chi, Robin Yonggui, Hammond, Paula T., Yang, Liang, Gan, Yunn-Hwen, Pethe, Kevin, Greenberg, E. Peter, Gründling, Angelika, Chan-Park, Mary B.
Published 2021

A glycosylated cationic block poly (β‐peptide) reverses intrinsic antibiotic resistance in all ESKAPE Gram‐negative bacteria

by Si, Zhangyong, Lim, Hui Wen, Tay, Moon Yue Feng, Du, Yu, Ruan, Lin, Qiu, Haofeng, Zamudio-Vazquez, Rubí, Reghu, Sheethal, Chen, Yahua, Tiong, Wen Shuo, Marimuthu, Kalisvar, De, Partha Pratim, Ng, Oon Tek, Zhu, Yabin, Gan, Yunn-Hwen, Chi, Robin Yonggui, Duan, Hongwei, Bazan, Guillermo C., Greenberg, E. Peter, Chan-Park, Mary Bee Eng, Pethe, Kevin
Published 2020