A glycosylated cationic block poly (β‐peptide) reverses intrinsic antibiotic resistance in all ESKAPE Gram‐negative bacteria

• Main Authors: Si, Zhangyong, Lim, Hui Wen, Tay, Moon Yue Feng, Du, Yu, Ruan, Lin, Qiu, Haofeng, Zamudio-Vazquez, Rubí, Reghu, Sheethal, Chen, Yahua, Tiong, Wen Shuo, Marimuthu, Kalisvar, De, Partha Pratim, Ng, Oon Tek, Zhu, Yabin, Gan, Yunn-Hwen, Chi, Robin Yonggui, Duan, Hongwei, Bazan, Guillermo C., Greenberg, E. Peter, Chan-Park, Mary Bee Eng, Pethe, Kevin
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2020
• Subjects: Engineering::Bioengineering; Antimicrobial Resistance; β-peptides
• Online Access: https://hdl.handle.net/10356/138782
• Institution: Nanyang Technological University

Carbapenem‐resistant Gram‐negative bacteria (GNB) are heading the list of pathogens for which antibiotics are the most critically needed. Many antibiotics are either unable to penetrate the outer‐membrane or are excluded by efflux mechanisms. Here, we report a cationic block β‐peptide (PAS8‐b‐PDM12)...