Complement-activated vitronectin enhances the invasion of nonphagocytic cells by bacterial pathogens <i>Burkholderia</i> and <i>Klebsiella</i>

by Tan, Yi Han, Gamage, Akshamal M, Gan, Yunn-Hwen
Published 2024

The proteobacterial species Burkholderia pseudomallei produces ergothioneine, which enhances virulence in mammalian infection

by Gamage, Akshamal M, Liao, Cangsong, Cheah, Irwin K, Chen, Yahua, Lim, Daniel RX, Ku, Joanne WK, Chee, Rhonda Sin Ling, Gengenbacher, Martin, Seebeck, Florian P, Halliwell, Barry, Gan, Yunn-Hwen
Published 2023

Generation of self-replicating airway organoids from the cave nectar bat Eonycteris spelaea as a model system for studying host-pathogen interactions in the bat airway epithelium

by Chan, Louisa L. Y., Gamage, Akshamal M., Tan, Chee Wah, Tan, Kai Sen, Liu, Jing, Tay, Douglas Jie Wen, Foo, Randy Jee Hiang, Rénia, Laurent, Wang, De Yun, Wang, Lin-Fa
Published 2023

Human Nasal Epithelial Cells Sustain Persistent SARS-CoV-2 Infection In Vitro, despite Eliciting a Prolonged Antiviral Response

by Gamage, Akshamal M, Tan, Kai Sen, Chan, Wharton OY, Lew, Zhe Zhang Ryan, Liu, Jing, Tan, Chee Wah, Rajagopalan, Deepa, Lin, Quy Xiao Xuan, Tan, Le Min, Venkatesh, Prasanna Nori, Ong, Yew Kwang, Thong, Mark, Lin, Raymond Tzer Pin, Prabhakar, Shyam, Wang, De Yun, Wang, Lin-Fa
Published 2022

The establishment of COPD organoids to study host-pathogen interaction reveals enhanced viral fitness of SARS-CoV-2 in bronchi

by Chan, Louisa L. Y., Anderson, Danielle E., Cheng, Hong Sheng, Ivan, Fransiskus Xaverius, Chen, Si, Kang, Adrian E. Z., Foo, Randy, Gamage, Akshamal M., Tiew, Pei Yee, Koh, Mariko Siyue, Lee, Ken Cheah Hooi, Nichol, Kristy, Pathinayake, Prabuddha S., Chan, Yik Lung, Yeo, Tsin Wen, Oliver, Brian G., Wark, Peter A. B., Liu, Linbo, Tan, Nguan Soon, Wang, Lin-Fa, Chotirmall, Sanjay Haresh
Published 2023

Longitudinal single cell atlas identifies complex temporal relationship between type I interferon response and COVID-19 severity

by Lin, Quy Xiao Xuan, Rajagopalan, Deepa, Gamage, Akshamal M., Tan, Le Min, Venkatesh, Prasanna Nori, Chan, Wharton O. Y., Kumar, Dilip, Agrawal, Ragini, Chen, Yao, Fong, Siew-Wai, Singh, Amit, Sun, Louisa J., Tan, Seow-Yen, Chai, Louis Yi Ann, Somani, Jyoti, Lee, Bernett, Renia, Laurent, Ng, Lisa F. P., Ramanathan, Kollengode, Wang, Lin-Fa, Young, Barnaby, Lye, David, Singhal, Amit, Prabhakar, Shyam
Published 2024